Visible Photorelease of Liquid Biopsy Markers Following Microfluidic Affinity-enrichment

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2020 Mar 13

PMID 32163053

Citations 10

Authors

Thilanga N Pahattuge

J Matt Jackson

Rane Digamber

Harshani Wijerathne

Virginia Brown

Malgorzata A Witek

Chamani Perera

Richard S Givens

Blake R Peterson

Steven A Soper

Affiliations

Soon will be listed here.

Abstract

We detail a heterobifunctional, 7-aminocoumarin photocleavable (PC) linker with unique properties to covalently attach Abs to surfaces and subsequently release them with visible light (400-450 nm). The PC linker allowed rapid (2 min) and efficient (>90%) release of CTCs and EVs without damaging their molecular cargo.

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