Myeloid Cell-derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2015 Jan 13

PMID 25579427

Citations 57

Authors

Hyun-Jeong Kwak

Peng Liu

Besnik Bajrami

Yuanfu Xu

Shin-Young Park

Cesar Nombela-Arrieta

Subhanjan Mondal

Yan Sun

Haiyan Zhu

Li Chai

Leslie E Silberstein

Tao Cheng

Hongbo R Luo

Affiliations

Soon will be listed here.

Abstract

The cellular mechanisms controlling infection-induced emergency granulopoiesis are poorly defined. Here we found that reactive oxygen species (ROS) concentrations in the bone marrow (BM) were elevated during acute infection in a phagocytic NADPH oxidase-dependent manner in myeloid cells. Gr1(+) myeloid cells were uniformly distributed in the BM, and all c-kit(+) progenitor cells were adjacent to Gr1(+) myeloid cells. Inflammation-induced ROS production in the BM played a critical role in myeloid progenitor expansion during emergency granulopoiesis. ROS elicited oxidation and deactivation of phosphatase and tensin homolog (PTEN), resulting in upregulation of PtdIns(3,4,5)P3 signaling in BM myeloid progenitors. We further revealed that BM myeloid cell-produced ROS stimulated proliferation of myeloid progenitors via a paracrine mechanism. Taken together, our results establish that phagocytic NADPH oxidase-mediated ROS production by BM myeloid cells plays a critical role in mediating emergency granulopoiesis during acute infection.

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