Redox Regulation of PTEN by Reactive Oxygen Species: Its Role in Physiological Processes

Overview

Journal Antioxidants (Basel)

Date 2024 Feb 24

PMID 38397797

Authors

Vu Hoang Trinh

Thang Nguyen Huu

Dhiraj Kumar Sah

Jin Myung Choi

Hyun Joong Yoon

Sang Chul Park

Yu Seok Jung

Seung-Rock Lee

Affiliations

Soon will be listed here.

Abstract

Phosphatase and tensin homolog (PTEN) is a tumor suppressor due to its ability to regulate cell survival, growth, and proliferation by downregulating the PI3K/AKT signaling pathway. In addition, PTEN plays an essential role in other physiological events associated with cell growth demands, such as ischemia-reperfusion, nerve injury, and immune responsiveness. Therefore, recently, PTEN inhibition has emerged as a potential therapeutic intervention in these situations. Increasing evidence demonstrates that reactive oxygen species (ROS), especially hydrogen peroxide (HO), are produced and required for the signaling in many important cellular processes under such physiological conditions. ROS have been shown to oxidize PTEN at the cysteine residue of its active site, consequently inhibiting its function. Herein, we provide an overview of studies that highlight the role of the oxidative inhibition of PTEN in physiological processes.

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