Yuanfu Xu
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Explore the profile of Yuanfu Xu including associated specialties, affiliations and a list of published articles.
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43
Citations
1195
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Recent Articles
1.
Hsu A, Huang Q, Pi X, Fu J, Raghunathan K, Ghimire L, et al.
Cell
. 2025 Feb;
PMID: 39938514
Although subsets with immunosuppressive properties exist, neutrophils are typically known for their pro-inflammatory role and pathogen clearance capabilities. Here, we reveal that neutrophils can paradoxically aid in resolving inflammation by...
2.
Chen R, Cheng T, Xie S, Sun X, Chen M, Zhao S, et al.
Adv Sci (Weinh)
. 2024 Jul;
11(38):e2402332.
PMID: 39049685
Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are common hematological malignancies in adults. Despite considerable research advances, the development of standard therapies, supportive care, and prognosis for the...
3.
Liu H, Sun L, Zhao H, Zhao Z, Zhang S, Jiang S, et al.
Cell Death Differ
. 2024 Apr;
31(6):697-710.
PMID: 38589495
Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that controls differentiation remains elusive. Here, we show that the genetic elimination...
4.
Hosaka K, Wang C, Zhang S, Lv X, Seki T, Zhang Y, et al.
Cancer Commun (Lond)
. 2023 Apr;
43(6):637-660.
PMID: 37120719
Background: Tumors possess incessant growth features, and expansion of their masses demands sufficient oxygen supply by red blood cells (RBCs). In adult mammals, the bone marrow (BM) is the main...
5.
Cao Y, Wang J, Jiang S, Lyu M, Zhao F, Liu J, et al.
Clin Transl Immunology
. 2023 Mar;
12(2):e1441.
PMID: 36855558
Objectives: Ruxolitinib, a Janus kinase (JAK) 1/2 inhibitor, demonstrates efficacy for treating steroid-resistant acute graft-versus-host disease (SR-aGVHD) following allogeneic stem cell transplantation (allo-HSCT). Myeloid-derived suppressor cells (MDSCs) have a protective...
6.
Fan Y, Teng Y, Loison F, Pang A, Kasorn A, Shao X, et al.
Sci Transl Med
. 2021 Jul;
13(604).
PMID: 34321317
Clinical outcomes from granulocyte transfusion (GTX) are disadvantaged by the short shelf life and compromised function of donor neutrophils. Spontaneous neutrophil death is heterogeneous and mediated by multiple pathways. Leveraging...
7.
Wang M, Wang H, Wen Y, Chen X, Liu X, Gao J, et al.
Stem Cell Res Ther
. 2020 Oct;
11(1):446.
PMID: 33076973
An amendment to this paper has been published and can be accessed via the original article.
8.
Xie X, Shi Q, Wu P, Zhang X, Kambara H, Su J, et al.
Nat Immunol
. 2020 Jul;
21(9):1119-1133.
PMID: 32719519
The full neutrophil heterogeneity and differentiation landscape remains incompletely characterized. Here, we profiled >25,000 differentiating and mature mouse neutrophils using single-cell RNA sequencing to provide a comprehensive transcriptional landscape of...
9.
Hosaka K, Yang Y, Seki T, Du Q, Jing X, He X, et al.
Nat Commun
. 2020 Jul;
11(1):3704.
PMID: 32709869
FGF-2 displays multifarious functions in regulation of angiogenesis and vascular remodeling. However, effective drugs for treating FGF-2 tumors are unavailable. Here we show that FGF-2 modulates tumor vessels by recruiting...
10.
Zhang X, Karatepe K, Chiewchengchol D, Zhu H, Guo R, Liu P, et al.
Front Immunol
. 2020 May;
11:626.
PMID: 32373117
Pathogen-initiated chronic inflammation or autoimmune diseases accelerate proliferation and promote differentiation of hematopoietic stem cells (HSCs) but simultaneously reduce reconstitution capacity. Nevertheless, the effect of acute infection and inflammation on...