The Role of Immune Cells Settled in the Bone Marrow on Adult Hematopoietic Stem Cells

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2024 Oct 5

PMID 39367881

Authors

Hui Xu

Yinghui Li

Yingdai Gao

Affiliations

Soon will be listed here.

Abstract

Certain immune cells, including neutrophils, macrophages, dendritic cells, B cells, Breg cells, CD4 T cells, CD8 T cells, and Treg cells, establish enduring residency within the bone marrow. Their distinctive interactions with hematopoiesis and the bone marrow microenvironment are becoming increasingly recognized alongside their multifaceted immune functions. These cells play a dual role in shaping hematopoiesis. They directly influence the quiescence, self-renewal, and multi-lineage differentiation of hematopoietic stem and progenitor cells through either direct cell-to-cell interactions or the secretion of various factors known for their immunological functions. Additionally, they actively engage with the cellular constituents of the bone marrow niche, particularly mesenchymal stem cells, endothelial cells, osteoblasts, and osteoclasts, to promote their survival and contribute to tissue repair, thereby fostering a supportive environment for hematopoietic stem and progenitor cells. Importantly, these bone marrow immune cells function synergistically, both locally and functionally, rather than in isolation. In summary, immune cells residing in the bone marrow are pivotal components of a sophisticated network of regulating hematopoiesis.

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