An Analysis of the Association Between a Polymorphism of KCNJ11 and Diabetic Retinopathy in a Chinese Han Population

Overview

Journal Eur J Med Res

Publisher Biomed Central

Specialty General Medicine

Date 2015 Jan 10

PMID 25573672

Citations 7

Authors

Nai-Jia Liu

Hui-Hui Wu

Yan-Liang Li

Zhen Yang

Xiao-Ming Tao

Yan-Ping Du

Xuan-Chun Wang

Bin Lu

Zhao-Yun Zhang

Ren-Ming Hu

Jie Wen

Affiliations

Soon will be listed here.

Abstract

Background: Genome-wide association studies (GWAS) have reported that the polymorphism rs5219 of the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) is associated with type 2 diabetes mellitus (T2DM). Given that diabetic retinopathy (DR) is one of the most common microvascular complications of T2DM, GWAS have identified a number of potential susceptibility genes for DR. However, only a fraction of them have been replicated in different studies and show consistent genetic associations with the occurrence of DR. The aim of the present study was to investigate whether common variants of KCNJ11 confer DR in a cohort of the Chinese Han population.

Methods: A case-control study of 580 T2DM patients, including 105 T2DM with DR and 475 T2DM without DR was performed. A single nucleotide polymorphism (SNP) of KCNJ11 (rs5219) was genotyped, and its association with DR was explored using a dominant genetic model. Genotyping was performed by iPLEX technology. Univariate and multivariate logistic regression (MLR) analysis controlling for confounders was conducted to evaluate the association between rs5219 and DR.

Results: The A allele frequency of rs5219 was significantly higher in DR patients than that in the patients without DR (49.01% versus 38.68%, P <0.05). We found the minor A allele could increase the risk to develop DR (ORint = 1.58, 95% CI: 1.139 to 2.192 for allele and P = 0.006, ORint =1.607, 95% CI: 1.267 to 2.038 for genotype and P <0.001) in the Chinese Han population.

Conclusions: Our findings provided evidence that KCNJ11 was associated with DR in Chinese Han patients with T2DM.

Citing Articles

Association of E23K/rs5219 Gene Polymorphism with Type 2 Diabetes and Diabetes-Related Cardiovascular Disease.

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Polymorphisms in glucose homeostasis genes are associated with cardiovascular and renal parameters in patients with diabetic nephropathy.

Mota-Zamorano S, Gonzalez L, Robles N, Valdivielso J, Arevalo-Lorido J, Lopez-Gomez J Ann Med. 2022; 54(1):3039-3051.

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The E23K Polymorphism of and Diabetic Retinopathy in Northern Iran.

Alidoust L, Ajamian F, Abbaspour S, Sharafshah A, Keshavarz P Br J Biomed Sci. 2022; 79:10245.

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Unraveling the role of genetics in the pathogenesis of diabetic retinopathy.

Sharma A, Valle M, Beveridge C, Liu Y, Sharma S Eye (Lond). 2019; 33(4):534-541.

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