Update on Genetics and Diabetic Retinopathy

Overview

Journal Clin Ophthalmol

Publisher Dove Medical Press

Specialty Ophthalmology

Date 2015 Dec 10

PMID 26648684

Citations 27

Authors

Blake M Hampton

Stephen G Schwartz

Milam A Brantley Jr

Harry W Flynn Jr

Affiliations

Soon will be listed here.

Abstract

Clinical risk factors for diabetic retinopathy (DR), such as duration of disease and degree of glucose control, do not adequately predict disease progression in individual patients, suggesting the presence of a genetic component. Multiple smaller studies have investigated genotype-phenotype correlations in genes encoding vascular endothelial growth factor, aldose reductase, the receptor for advanced glycation end products, and many others. In general, reported results have been conflicting, due to factors including small sample sizes, variations in study design, differences in clinical end points, and underlying genetic differences between study groups. At this time, there is no confirmed association with any risk allele reported. As we continue to collect data from additional studies, the role of genetics in DR may become more apparent.

Citing Articles

Assessment of MIR200B Polymorphisms Association with Sight-Threatening Diabetic Retinopathy.

Zal N, Safi S, Ahmadieh H, Fekri S, Najafi S, Forouhari A J Curr Ophthalmol. 2024; 35(4):355-361.

PMID: 39281402 PMC: 11392297. DOI: 10.4103/joco.joco_287_22.

Genetic insights and emerging therapeutics in diabetic retinopathy: from molecular pathways to personalized medicine.

Pei X, Huang D, Li Z Front Genet. 2024; 15:1416924.

PMID: 39246572 PMC: 11378321. DOI: 10.3389/fgene.2024.1416924.

The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review.

Sienkiewicz-Szlapka E, Fiedorowicz E, Krol-Grzymala A, Kordulewska N, Rozmus D, Cieslinska A Int J Mol Sci. 2023; 24(21).

PMID: 37958858 PMC: 10650381. DOI: 10.3390/ijms242115865.

No Association of Angiotensin-Converting Enzyme Insertion/Deletion (ACE I/D) Gene Polymorphism in the Susceptibility to Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients: An Updated Meta-Analysis.

Coelho A, Silveira L, Santos K, Santos R, Reis A J Pers Med. 2023; 13(9).

PMID: 37763076 PMC: 10533192. DOI: 10.3390/jpm13091308.

The rs1800469 T/T and rs1800470 C/C genotypes of the TGFB1 gene confer protection against diabetic retinopathy in a Southern Brazilian population.

Costa A, Dieter C, Canani L, Assmann T, Crispim D Genet Mol Biol. 2023; 46(3):e20220247.

PMID: 37418683 PMC: 10328150. DOI: 10.1590/1678-4685-GMB-2022-0247.

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