CDKAL1 Rs7756992 is Associated with Diabetic Retinopathy in a Chinese Population with Type 2 Diabetes

Overview

Journal Sci Rep

Specialty Science

Date 2017 Aug 20

PMID 28821857

Citations 5

Authors

Danfeng Peng

Jie Wang

Rong Zhang

Feng Jiang

Claudia H T Tam

Guozhi Jiang

Tao Wang

Miao Chen

Jing Yan

Shiyun Wang

Dandan Yan

Zhen He

Ronald C W Ma

Yuqian Bao

Cheng Hu

Weiping Jia

Affiliations

Soon will be listed here.

Abstract

Diabetic retinopathy (DR) is a major microvascular complication of diabetes. Susceptibility genes for type 2 diabetes may also impact the susceptibility of DR. This case-control study investigated the effects of 88 type 2 diabetes susceptibility loci on DR in a Chinese population with type 2 diabetes performed in two stages. In stage 1, 88 SNPs were genotyped in 1,251 patients with type 2 diabetes, and we found that ADAMTS9-AS2 rs4607103, WFS1 rs10010131, CDKAL1 rs7756992, VPS26A rs1802295 and IDE-KIF11-HHEX rs1111875 were significantly associated with DR. The association between CDKAL1 rs7756992 and DR remained significant after Bonferroni correction for multiple comparisons (corrected P = 0.0492). Then, the effect of rs7756992 on DR were analysed in two independent cohorts for replication in stage 2. Cohort (1) consisted of 380 patients with DR and 613 patients with diabetes for ≥5 years but without DR. Cohort (2) consisted of 545 patients with DR and 929 patients with diabetes for ≥5 years but without DR. A meta-analysis combining the results of stage 1 and 2 revealed a significant association between rs7756992 and DR, with the minor allele A conferring a lower risk of DR (OR 0.824, 95% CI 0.743-0.914, P = 2.46 × 10).

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