Risk Factors Associated with Retinal Neovascularization of Diabetic Retinopathy in Type 2 Diabetes Mellitus

Overview

Journal Int J Ophthalmol

Specialty Ophthalmology

Date 2012 May 4

PMID 22553638

Citations 20

Authors

Ze-Long Zhong

Mei Han

Song Chen

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the risk factors associated with retinal neovascularization of diabetic retinopathy in northern Chinese Han patients with type 2 diabetes mellitus (T2DM).

Methods: The clinical characteristics of 200 patients with proliferative diabetic retinopathy (PDR) and 100 age-matched healthy individuals were compared. The univariate and multivariate logistic regression analysis were performed in the patients with PDR.

Results: Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), blood urea nitrogen (BUN), uric acid (UA), white blood cell count (WBC), absolute neutrophil count, hematocrit (HCT) and mean platelet volume (MPV) and mean platelet volume (MPV) were all significantly higher in patients with PDR than in the control group (P<0.05). The univariate and multivariate logistic regression analysis showed that risk factors independently associated with retinal neovascularization of DR were duration of diabetes mellitus (OR=1.112; P=0.000), BUN (OR=1.277; P=0.000), smoking (OR=3.967; P=0.000) and MPV (OR=2.472; P=0.000). On the other hand, panretinal photocoagulation was associated with reduced risk of retinal neovascularization (OR=0.983; P=0.000).

Conclusion: Preventing and controlling T2DM in terms of risk factors, including duration of diabetes, BUN, smoking and MPV, might offer novel approaches to prevent or delay the onset of retinal neovascularization in patients with PDR.

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References

Luk A, So W, Ma R, Kong A, Ozaki R, Ng V . Metabolic syndrome predicts new onset of chronic kidney disease in 5,829 patients with type 2 diabetes: a 5-year prospective analysis of the Hong Kong Diabetes Registry. Diabetes Care. 2008; 31(12):2357-61. PMC: 2584195. DOI: 10.2337/dc08-0971. View

Pradeepa R, Anitha B, Mohan V, Ganesan A, Rema M . Risk factors for diabetic retinopathy in a South Indian Type 2 diabetic population--the Chennai Urban Rural Epidemiology Study (CURES) Eye Study 4. Diabet Med. 2008; 25(5):536-42. DOI: 10.1111/j.1464-5491.2008.02423.x. View

Khandekar M, Khurana A, Deshmukh S, Kakrani A, Katdare A, Inamdar A . Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol. 2006; 59(2):146-9. PMC: 1860313. DOI: 10.1136/jcp.2004.025387. View

Bamashmus M, Gunaid A, Khandekar R . Diabetic retinopathy, visual impairment and ocular status among patients with diabetes mellitus in Yemen: a hospital-based study. Indian J Ophthalmol. 2009; 57(4):293-8. PMC: 2712699. DOI: 10.4103/0301-4738.53055. View

. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997; 20(7):1183-97. DOI: 10.2337/diacare.20.7.1183. View

Leitao C, Canani L, Silveiro S, Gross J . Ambulatory blood pressure monitoring and type 2 diabetes mellitus. Arq Bras Cardiol. 2007; 89(5):315-21, 347-54. DOI: 10.1590/s0066-782x2007001700012. View

Chatziralli I, Sergentanis T, Keryttopoulos P, Vatkalis N, Agorastos A, Papazisis L . Risk factors associated with diabetic retinopathy in patients with diabetes mellitus type 2. BMC Res Notes. 2010; 3:153. PMC: 2888829. DOI: 10.1186/1756-0500-3-153. View

Yam J, Kwok A . Update on the treatment of diabetic retinopathy. Hong Kong Med J. 2007; 13(1):46-60. View

Rani P, Raman R, Chandrakantan A, Pal S, Perumal G, Sharma T . Risk factors for diabetic retinopathy in self-reported rural population with diabetes. J Postgrad Med. 2009; 55(2):92-6. DOI: 10.4103/0022-3859.48787. View

10.

Rodrigues T, Pecis M, Azevedo M, Gross J . [Blood pressure homeostasis and microvascular complications in diabetic patients]. Arq Bras Endocrinol Metabol. 2006; 49(6):882-90. DOI: 10.1590/s0004-27302005000600005. View

11.

Cai X, Wang F, Ji L . Risk factors of diabetic retinopathy in type 2 diabetic patients. Chin Med J (Engl). 2006; 119(10):822-6. View

12.

Xie X, Xu L, Wang Y, Jonas J . Prevalence and associated factors of diabetic retinopathy. The Beijing Eye Study 2006. Graefes Arch Clin Exp Ophthalmol. 2008; 246(11):1519-26. DOI: 10.1007/s00417-008-0884-6. View

13.

Eliasson B . Cigarette smoking and diabetes. Prog Cardiovasc Dis. 2003; 45(5):405-13. DOI: 10.1053/pcad.2003.00103. View

14.

Wilkinson C, Ferris 3rd F, Klein R, Lee P, Agardh C, Davis M . Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003; 110(9):1677-82. DOI: 10.1016/S0161-6420(03)00475-5. View

15.

Tavil Y, Sen N, Yazici H, Hizal F, Abaci A, Cengel A . Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res. 2006; 120(2):245-50. DOI: 10.1016/j.thromres.2006.10.005. View

16.

Shah C . Diabetic retinopathy: A comprehensive review. Indian J Med Sci. 2009; 62(12):500-19. View

17.

Chan J, Malik V, Jia W, Kadowaki T, Yajnik C, Yoon K . Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA. 2009; 301(20):2129-40. DOI: 10.1001/jama.2009.726. View

18.

van Leiden H, Dekker J, Moll A, Nijpels G, Heine R, Bouter L . Risk factors for incident retinopathy in a diabetic and nondiabetic population: the Hoorn study. Arch Ophthalmol. 2003; 121(2):245-51. DOI: 10.1001/archopht.121.2.245. View