Diagnosing Lung Carcinomas with Optical Coherence Tomography

Overview

Journal Ann Am Thorac Soc

Specialty Pulmonary Medicine

Date 2015 Jan 7

PMID 25562183

Citations 24

Authors

Lida P Hariri

Mari Mino-Kenudson

Michael Lanuti

Alyssa J Miller

Eugene J Mark

Melissa J Suter

Affiliations

Soon will be listed here.

Abstract

Rationale: Lung carcinoma diagnosis on tissue biopsy can be challenging because of insufficient tumor and lack of architectural information. Optical coherence tomography (OCT) is a high-resolution imaging modality that visualizes tissue microarchitecture in volumes orders of magnitude larger than biopsy. It has been proposed that OCT could potentially replace tissue biopsy.

Objectives: We aim to determine whether OCT could replace histology in diagnosing lung carcinomas. We develop and validate OCT interpretation criteria for common primary lung carcinomas: adenocarcinoma, squamous cell carcinoma (SCC), and poorly differentiated carcinoma.

Methods: A total of 82 ex vivo tumor samples were included in a blinded assessment with 3 independent readers. Readers were trained on the OCT criteria, and applied these criteria to diagnose adenocarcinoma, SCC, or poorly differentiated carcinoma in an OCT validation dataset. After a 7-month period, the readers repeated the training and validation dataset interpretation. An independent pathologist reviewed corresponding histology.

Measurements And Main Results: The average accuracy achieved by the readers was 82.6% (range, 73.7-94.7%). The sensitivity and specificity for adenocarcinoma were 80.3% (65.7-91.4%) and 88.6% (80.5-97.6%), respectively. The sensitivity and specificity for SCC were 83.3% (70.0-100.0%) and 87.0% (75.0-96.5%), respectively. The sensitivity and specificity for poorly differentiated carcinoma were 85.7% (81.0-95.2%) and 97.6% (92.9-100.0%), respectively.

Conclusions: Although these results are encouraging, they indicate that OCT cannot replace histology in the diagnosis of lung carcinomas. However, OCT has potential to aid in diagnosing lung carcinomas as a complement to tissue biopsy, particularly when insufficient tissue is available for pathology assessment.

Citing Articles

Spatial lung imaging in clinical and translational settings.

Mahmutovic Persson I, Bozovic G, Westergren-Thorsson G, Rolandsson Enes S Breathe (Sheff). 2024; 20(3):230224.

PMID: 39360023 PMC: 11444490. DOI: 10.1183/20734735.0224-2023.

Motor-free telerobotic endomicroscopy for steerable and programmable imaging in complex curved and localized areas.

Yuan S, Xu C, Cui B, Zhang T, Liang B, Yuan W Nat Commun. 2024; 15(1):7680.

PMID: 39227604 PMC: 11372151. DOI: 10.1038/s41467-024-51633-x.

Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation.

Rabindran B, Corben A Pathol Oncol Res. 2023; 29:1611167.

PMID: 37521364 PMC: 10374948. DOI: 10.3389/pore.2023.1611167.

Optical coherence tomography.

Bouma B, de Boer J, Huang D, Jang I, Yonetsu T, Leggett C Nat Rev Methods Primers. 2023; 2.

PMID: 36751306 PMC: 9901537. DOI: 10.1038/s43586-022-00162-2.

Novel image features of optical coherence tomography for pathological classification of lung cancer: Results from a prospective clinical trial.

Zhu Q, Yu H, Liang Z, Zhao W, Zhu M, Xu Y Front Oncol. 2022; 12:870556.

PMID: 36338729 PMC: 9634220. DOI: 10.3389/fonc.2022.870556.

References

Quirk B, McLaughlin R, Curatolo A, Kirk R, Noble P, Sampson D . In situ imaging of lung alveoli with an optical coherence tomography needle probe. J Biomed Opt. 2011; 16(3):036009. DOI: 10.1117/1.3556719. View

Kuo W, Kim J, Shemonski N, Chaney E, Spillman Jr D, Boppart S . Real-time three-dimensional optical coherence tomography image-guided core-needle biopsy system. Biomed Opt Express. 2012; 3(6):1149-61. PMC: 3370958. DOI: 10.1364/BOE.3.001149. View

Hariri L, Mino-Kenudson M, Mark E, Suter M . In vivo optical coherence tomography: the role of the pathologist. Arch Pathol Lab Med. 2012; 136(12):1492-501. DOI: 10.5858/arpa.2012-0252-SA. View

Hou R, Le T, Murgu S, Chen Z, Brenner M . Recent advances in optical coherence tomography for the diagnoses of lung disorders. Expert Rev Respir Med. 2011; 5(5):711-24. PMC: 3393648. DOI: 10.1586/ers.11.59. View

Hariri L, Applegate M, Mino-Kenudson M, Mark E, Bouma B, Tearney G . Optical frequency domain imaging of ex vivo pulmonary resection specimens: obtaining one to one image to histopathology correlation. J Vis Exp. 2013; (71). PMC: 3582683. DOI: 10.3791/3855. View

Suter M, Lam S, Brenner M . Optical techniques in pulmonary medicine. SPIE photonics West. Expert Rev Respir Med. 2012; 6(2):143-5. DOI: 10.1586/ers.12.11. View

Michel R, Kinasewitz G, Fung K, Keddissi J . Optical coherence tomography as an adjunct to flexible bronchoscopy in the diagnosis of lung cancer: a pilot study. Chest. 2010; 138(4):984-8. DOI: 10.1378/chest.10-0753. View

Evans J, Bouma B, Bressner J, Shishkov M, Lauwers G, Mino-Kenudson M . Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography. Gastrointest Endosc. 2006; 65(1):50-6. PMC: 2719434. DOI: 10.1016/j.gie.2006.04.027. View

Baaklini W, REINOSO M, Gorin A, Sharafkaneh A, Manian P . Diagnostic yield of fiberoptic bronchoscopy in evaluating solitary pulmonary nodules. Chest. 2000; 117(4):1049-54. DOI: 10.1378/chest.117.4.1049. View

10.

Cooper W, OToole S, Boyer M, Horvath L, Mahar A . What's new in non-small cell lung cancer for pathologists: the importance of accurate subtyping, EGFR mutations and ALK rearrangements. Pathology. 2011; 43(2):103-15. DOI: 10.1097/PAT.0b013e328342629d. View

11.

Suter M, Vakoc B, Yachimski P, Shishkov M, Lauwers G, Mino-Kenudson M . Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging. Gastrointest Endosc. 2008; 68(4):745-53. PMC: 2715833. DOI: 10.1016/j.gie.2008.05.014. View

12.

Hariri L, Villiger M, Applegate M, Mino-Kenudson M, Mark E, Bouma B . Seeing beyond the bronchoscope to increase the diagnostic yield of bronchoscopic biopsy. Am J Respir Crit Care Med. 2013; 187(2):125-9. PMC: 3570655. DOI: 10.1164/rccm.201208-1483OE. View

13.

Hariri L, Mino-Kenudson M, Applegate M, Mark E, Tearney G, Lanuti M . Toward the guidance of transbronchial biopsy: identifying pulmonary nodules with optical coherence tomography. Chest. 2013; 144(4):1261-1268. PMC: 3787917. DOI: 10.1378/chest.13-0534. View

14.

Rivera M, Mehta A . Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 2007; 132(3 Suppl):131S-148S. DOI: 10.1378/chest.07-1357. View

15.

da Cunha Santos G, Lai S, Saieg M, Geddie W, Pintilie M, Tsao M . Cyto-histologic agreement in pathologic subtyping of non small cell lung carcinoma: review of 602 fine needle aspirates with follow-up surgical specimens over a nine year period and analysis of factors underlying failure to subtype. Lung Cancer. 2012; 77(3):501-6. DOI: 10.1016/j.lungcan.2012.05.091. View

16.

Su J, Zhang J, Yu L, Colt H, Brenner M, Chen Z . Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor. J Biomed Opt. 2008; 13(3):030506. PMC: 2777978. DOI: 10.1117/1.2938700. View

17.

Coxson H, Quiney B, Sin D, Xing L, McWilliams A, Mayo J . Airway wall thickness assessed using computed tomography and optical coherence tomography. Am J Respir Crit Care Med. 2008; 177(11):1201-6. PMC: 2408438. DOI: 10.1164/rccm.200712-1776OC. View

18.

Huang D, Swanson E, Lin C, Schuman J, Stinson W, Chang W . Optical coherence tomography. Science. 1991; 254(5035):1178-81. PMC: 4638169. DOI: 10.1126/science.1957169. View

19.

Yun S, Tearney G, Vakoc B, Shishkov M, Oh W, Desjardins A . Comprehensive volumetric optical microscopy in vivo. Nat Med. 2006; 12(12):1429-33. PMC: 2709216. DOI: 10.1038/nm1450. View

20.

Hanna N, Saltzman D, Mukai D, Chen Z, Sasse S, Milliken J . Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura. J Thorac Cardiovasc Surg. 2005; 129(3):615-22. DOI: 10.1016/j.jtcvs.2004.10.022. View