An Imagable and Photothermal "Abraxane-like" Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors

Overview

Journal Adv Mater

Date 2014 Dec 16

PMID 25504416

Citations 96

Authors

Qian Chen

Chao Liang

Chao Wang

Zhuang Liu

Affiliations

Soon will be listed here.

Abstract

A new "Abraxane-like" nanotheranostic formulation self-assembled from three clinically approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed. Utilizing such a newly formulated nanodrug, combined photothermal and chemotherapy is conducted under the guidance of imaging, not only effectively eliminating subcutaneous tumors, but also significantly inhibiting the development of metastatic tumors in this proof-of-concept study.

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