Triggered Ferroptotic Albumin-tocopherol Nanocarriers for Treating Drug-resistant Breast Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2024 Nov 7

PMID 39507754

Authors

Qianqian Gao

Tingting Liu

Li Sun

Yongliang Yao

Fang Li

Lingxiang Mao

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is considered an effective method to overcome drug-resistant tumors. This study aims to use three FDA-approved biological materials, human serum albumin, D-α-tocopherol succinate, and indocyanine green, to construct a novel biocompatible nanomaterial named HTI-NPs, exploring its effect in drug-resistant breast cancer (MCF-7/ADR cells). The research results indicate that HTI-NPs can selectively inhibit the proliferation of MCF-7/ADR cells , accompanied by upregulating transferrin receptor, generating reactive oxygen species, and downregulating glutathione peroxidase 4. Under laser irradiation, HTI-NPs can promote ferroptosis by inhibiting glutathione expression through photodynamic therapy. Notably, HTI-NPs exhibit good inhibitory effects on MCF-7/ADR xenograft tumors . In conclusion, HTI-NPs represent a biocompatible nanomaterial that induces ferroptosis, providing new insights and options for treating drug-resistant breast cancer.

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