Cyanine Dyes in the Mitochondria-targeting Photodynamic and Photothermal Therapy

Overview

Journal Commun Chem

Publisher Springer Nature

Specialty Chemistry

Date 2024 Aug 13

PMID 39138299

Authors

Zdenek Kejik

Jan Hajduch

Nikita Abramenko

Frederic Vellieux

Katerina Vesela

Jindriska Leischner Fialova

Katerina Petrlakova

Katerina Kucnirova

Robert Kaplanek

Ameneh Tatar

Marketa Skalickova

Michal Masarik

Petr Babula

Petr Dytrych

David Hoskovec

Pavel Martasek

Milan Jakubek

Affiliations

Soon will be listed here.

Abstract

Mitochondrial dysregulation plays a significant role in the carcinogenesis. On the other hand, its destabilization strongly represses the viability and metastatic potential of cancer cells. Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show significant potential in enhancing PDT and PTT. The potential and limitations of cyanine dyes for mitochondrial PDT and PTT are discussed, along with their applications in combination therapies, theranostic techniques, and optimal delivery systems. Additionally, novel approaches for sonodynamic therapy using photoactive cyanine dyes are presented, highlighting advances in cancer treatment.

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