The Impact of Tumor Microenvironment: Unraveling the Role of Physical Cues in Breast Cancer Progression

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2024 Jan 18

PMID 38238542

Authors

Ayuba Akinpelu

Tosin Akinsipe

L Adriana Avila

Robert D Arnold

Panagiotis Mistriotis

Affiliations

Soon will be listed here.

Abstract

Metastasis accounts for the vast majority of breast cancer-related fatalities. Although the contribution of genetic and epigenetic modifications to breast cancer progression has been widely acknowledged, emerging evidence underscores the pivotal role of physical stimuli in driving breast cancer metastasis. In this review, we summarize the changes in the mechanics of the breast cancer microenvironment and describe the various forces that impact migrating and circulating tumor cells throughout the metastatic process. We also discuss the mechanosensing and mechanotransducing molecules responsible for promoting the malignant phenotype in breast cancer cells. Gaining a comprehensive understanding of the mechanobiology of breast cancer carries substantial potential to propel progress in prognosis, diagnosis, and patient treatment.

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