Mir-23a and Mir-125b Regulate Neural Stem/progenitor Cell Proliferation by Targeting Musashi1

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2014 Dec 9

PMID 25483045

Citations 23

Authors

Ubaldo Gioia

Valerio Di Carlo

Pasquale Caramanica

Camilla Toselli

Antonella Cinquino

Marcella Marchioni

Pietro Laneve

Stefano Biagioni

Irene Bozzoni

Emanuele Cacci

Elisa Caffarelli

Affiliations

Soon will be listed here.

Abstract

Musashi1 is an RNA binding protein that controls the neural cell fate, being involved in maintaining neural progenitors in their proliferative state. In particular, its downregulation is needed for triggering early neural differentiation programs. In this study, we profiled microRNA expression during the transition from neural progenitors to differentiated astrocytes and underscored 2 upregulated microRNAs, miR-23a and miR-125b, that sinergically act to restrain Musashi1 expression, thus creating a regulatory module controlling neural progenitor proliferation.

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