Estimate of Tissue Composition in Malignant and Benign Breast Lesions by Time-domain Optical Mammography

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2014 Nov 1

PMID 25360382

Citations 26

Authors

Giovanna Quarto

Lorenzo Spinelli

Antonio Pifferi

Alessandro Torricelli

Rinaldo Cubeddu

Francesca Abbate

Nicola Balestreri

Simona Menna

Enrico Cassano

Paola Taroni

Affiliations

Soon will be listed here.

Abstract

The optical characterization of malignant and benign breast lesions is presented. Time-resolved transmittance measurements were performed in the 630-1060 nm range by means of a 7-wavelength optical mammograph, providing both imaging and spectroscopy information. A total of 62 lesions were analyzed, including 33 malignant and 29 benign lesions. The characterization of breast lesions was performed applying a perturbation model based on the high-order calculation of the pathlength of photons inside the lesion, which led to the assessment of oxy- and deoxy-hemoglobin, lipids, water and collagen concentrations. Significant variations between tumor and healthy tissue were observed in terms of both absorption properties and constituents concentration. In particular, benign lesions and tumors show a statistically significant discrimination in terms of absorption at several wavelengths and also in terms of oxy-hemoglobin and collagen content.

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