High Throughput Detection Chain for Time Domain Optical Mammography

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2018 Mar 20

PMID 29552410

Citations 11

Authors

Edoardo Ferocino

Edoardo Martinenghi

Alberto Dalla Mora

Antonio Pifferi

Rinaldo Cubeddu

Paola Taroni

Affiliations

Soon will be listed here.

Abstract

A novel detection chain, based on 8 Silicon Photomultipliers (forming a wide-area custom-made detection probe) and on a time-to-digital converter, was developed to improve the signal level in multi-wavelength (635-1060 nm) time domain optical mammography. The performances of individual components and of the overall chain were assessed using established protocols (BIP and MEDPHOT). The photon detection efficiency was improved by up to 3 orders of magnitude, and the maximum count rate level was increased by a factor of 10 when compared to the previous system, based on photomultiplier tubes and conventional time-correlated single-photon counting boards. In the estimate of optical parameters, the novel detection chain provides performances comparable to the previous system, widely validated in clinics, but with higher signal level, higher robustness, and at a lower price per channel, thus targeting important requirements for clinical applications.

Citing Articles

Monitoring of neoadjuvant chemotherapy through time domain diffuse optics: breast tissue composition changes and collagen discriminative potential.

Mule N, Maffeis G, Cubeddu R, Santangelo C, Bianchini G, Panizza P Biomed Opt Express. 2024; 15(8):4842-4858.

PMID: 39346975 PMC: 11427201. DOI: 10.1364/BOE.527968.

In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density.

Serra N, Cubeddu R, Maffeis G, Damagatla V, Pifferi A, Taroni P Sci Rep. 2024; 14(1):19154.

PMID: 39160254 PMC: 11333589. DOI: 10.1038/s41598-024-70099-x.

Water and lipid content of breast tissue measured by six-wavelength time-domain diffuse optical spectroscopy.

Wada H, Yoshizawa N, Ohmae E, Ueda Y, Yoshimoto K, Mimura T J Biomed Opt. 2022; 27(10).

PMID: 36229894 PMC: 9556800. DOI: 10.1117/1.JBO.27.10.105002.

Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise.

Lanka P, Yang L, Orive-Miguel D, Veesa J, Tagliabue S, Sudakou A J Biomed Opt. 2022; 27(7).

PMID: 35701869 PMC: 9199954. DOI: 10.1117/1.JBO.27.7.074716.

Silicon Photomultipliers for Deep Tissue Cerenkov Emission Detection During External Beam Radiotherapy.

Oraiqat I, DeBruin S, Pearce R, Como C, Mikell J, Taylor C IEEE Photonics J. 2021; 11(4).

PMID: 33747354 PMC: 7971172. DOI: 10.1109/jphot.2019.2931845.

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