Regulation of MicroRNA Function in Somatic Stem Cell Proliferation and Differentiation

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2014 Aug 15

PMID 25118717

Citations 177

Authors

Archana Shenoy

Robert H Blelloch

Affiliations

Soon will be listed here.

Abstract

microRNAs (miRNAs) are important modulators of development. Owing to their ability to simultaneously silence hundreds of target genes, they have key roles in large-scale transcriptomic changes that occur during cell fate transitions. In somatic stem and progenitor cells--such as those involved in myogenesis, haematopoiesis, skin and neural development--miRNA function is carefully regulated to promote and stabilize cell fate choice. miRNAs are integrated within networks that form both positive and negative feedback loops. Their function is regulated at multiple levels, including transcription, biogenesis, stability, availability and/or number of target sites, as well as their cooperation with other miRNAs and RNA-binding proteins. Together, these regulatory mechanisms result in a refined molecular response that enables proper cellular differentiation and function.

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References

Dugas J, Cuellar T, Scholze A, Ason B, Ibrahim A, Emery B . Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron. 2010; 65(5):597-611. PMC: 2843397. DOI: 10.1016/j.neuron.2010.01.027. View

Bernstein E, Kim S, Carmell M, Murchison E, Alcorn H, Li M . Dicer is essential for mouse development. Nat Genet. 2003; 35(3):215-7. DOI: 10.1038/ng1253. View

Visvanathan J, Lee S, Lee B, Lee J, Lee S . The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev. 2007; 21(7):744-9. PMC: 1838526. DOI: 10.1101/gad.1519107. View

Koralov S, Muljo S, Galler G, Krek A, Chakraborty T, Kanellopoulou C . Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008; 132(5):860-74. DOI: 10.1016/j.cell.2008.02.020. View

Van Rooij E, Quiat D, Johnson B, Sutherland L, Qi X, Richardson J . A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009; 17(5):662-73. PMC: 2796371. DOI: 10.1016/j.devcel.2009.10.013. View

Zhao X, He X, Han X, Yu Y, Ye F, Chen Y . MicroRNA-mediated control of oligodendrocyte differentiation. Neuron. 2010; 65(5):612-26. PMC: 2855245. DOI: 10.1016/j.neuron.2010.02.018. View

Yoo A, Sun A, Li L, Shcheglovitov A, Portmann T, Li Y . MicroRNA-mediated conversion of human fibroblasts to neurons. Nature. 2011; 476(7359):228-31. PMC: 3348862. DOI: 10.1038/nature10323. View

Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis M, Nervi C . A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis. Cell. 2005; 123(5):819-31. DOI: 10.1016/j.cell.2005.09.023. View

Lynn F, Skewes-Cox P, Kosaka Y, McManus M, Harfe B, German M . MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes. 2007; 56(12):2938-45. DOI: 10.2337/db07-0175. View

10.

Rao P, Kumar R, Farkhondeh M, Baskerville S, Lodish H . Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A. 2006; 103(23):8721-6. PMC: 1482645. DOI: 10.1073/pnas.0602831103. View

11.

Bonev B, Pisco A, Papalopulu N . MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis. Dev Cell. 2011; 20(1):19-32. PMC: 3361082. DOI: 10.1016/j.devcel.2010.11.018. View

12.

Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R . DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet. 2007; 39(3):380-5. PMC: 3008549. DOI: 10.1038/ng1969. View

13.

Naka-Kaneda H, Nakamura S, Igarashi M, Aoi H, Kanki H, Tsuyama J . The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells. Proc Natl Acad Sci U S A. 2014; 111(4):1604-9. PMC: 3910627. DOI: 10.1073/pnas.1315567111. View

14.

De Pietri Tonelli D, Pulvers J, Haffner C, Murchison E, Hannon G, Huttner W . miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development. 2008; 135(23):3911-21. PMC: 2798592. DOI: 10.1242/dev.025080. View

15.

Shenoy A, Blelloch R . microRNA induced transdifferentiation. F1000 Biol Rep. 2012; 4:3. PMC: 3270586. DOI: 10.3410/B4-3. View

16.

Lu J, Guo S, Ebert B, Zhang H, Peng X, Bosco J . MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell. 2008; 14(6):843-53. PMC: 2688789. DOI: 10.1016/j.devcel.2008.03.012. View

17.

Sarkar S, Dey B, Dutta A . MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A. Mol Biol Cell. 2010; 21(13):2138-49. PMC: 2893979. DOI: 10.1091/mbc.e10-01-0062. View

18.

Cardinali B, Castellani L, Fasanaro P, Basso A, Alema S, Martelli F . Microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells. PLoS One. 2009; 4(10):e7607. PMC: 2762614. DOI: 10.1371/journal.pone.0007607. View

19.

Liu C, Teng Z, McQuate A, Jobe E, Christ C, von Hoyningen-Huene S . An epigenetic feedback regulatory loop involving microRNA-195 and MBD1 governs neural stem cell differentiation. PLoS One. 2013; 8(1):e51436. PMC: 3547917. DOI: 10.1371/journal.pone.0051436. View

20.

Dore L, Amigo J, Dos Santos C, Zhang Z, Gai X, Tobias J . A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A. 2008; 105(9):3333-8. PMC: 2265118. DOI: 10.1073/pnas.0712312105. View