Identical Peptides Recognized by MHC Class I- and II-restricted T Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1989 Jul 1

PMID 2501446

Citations 14

Authors

D L Perkins

M Z Lai

J A Smith

M L Gefter

Affiliations

Soon will be listed here.

Abstract

Previous data from many groups show that both class I and class II-restricted T cells recognize short synthetic peptides in the context of their respective MHC molecules (9-18), all of the peptides described to date are restricted to only a single class of MHC molecules; however, structural homology between the class I and II MHC molecules and the use of similar TCRs by class I and II-restricted T cells suggest that antigen recognition mechanisms are similar in both systems. To directly compare antigen recognition in the two systems, we analyzed peptides for the ability to function in both a class I and II-restricted system and found that seven of seven individual peptides tested stimulate both class I and II-restricted T cell responses. In addition, two of the peptides can function in different species stimulating both human class I and murine class II T cell responses. Thus, the process of T cell recognition of antigen in the context of MHC molecules was highly conserved in evolution not only between the class I and class II MHC systems, but also between the murine and human species.

Citing Articles

Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens.

Jepson A, Banya W, Sisay-Joof F, Hassan-King M, Nunes C, Bennett S Infect Immun. 1997; 65(3):872-6.

PMID: 9038290 PMC: 175062. DOI: 10.1128/IAI.65.3.872-876.1997.

Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model.

Krinzman S, De Sanctis G, Cernadas M, Mark D, Wang Y, Listman J J Clin Invest. 1996; 98(12):2693-9.

PMID: 8981913 PMC: 507732. DOI: 10.1172/JCI119093.

Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes.

Ikonomidis G, Paterson Y, Kos F, Portnoy D J Exp Med. 1994; 180(6):2209-18.

PMID: 7964496 PMC: 2191788. DOI: 10.1084/jem.180.6.2209.

Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.

Weidt G, Deppert W, Buchhop S, Dralle H, Lehmann-Grube F J Virol. 1995; 69(4):2654-8.

PMID: 7533861 PMC: 188949. DOI: 10.1128/JVI.69.4.2654-2658.1995.

Delineation of antigen contact residues on an MHC class II molecule.

Peccoud J, Dellabona P, Allen P, Benoist C, Mathis D EMBO J. 1990; 9(13):4215-23.

PMID: 2265605 PMC: 552203. DOI: 10.1002/j.1460-2075.1990.tb07869.x.

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