Oxygen-enhanced 3D Radial Ultrashort Echo Time Magnetic Resonance Imaging in the Healthy Human Lung

Overview

Journal NMR Biomed

Publisher Wiley

Date 2014 Jul 3

PMID 24984695

Citations 23

Authors

Stanley J Kruger

Sean B Fain

Kevin M Johnson

Robert V Cadman

Scott K Nagle

Affiliations

Soon will be listed here.

Abstract

The purpose of this work was to use 3D radial ultrashort echo time (UTE) MRI to perform whole-lung oxygen-enhanced (OE) imaging in humans. Eight healthy human subjects underwent two 3D radial UTE MRI acquisitions (TE = 0.08 ms): one while breathing 21% O2 and the other while breathing 100% O2. Scans were each performed over 5 min of free breathing, using prospective respiratory gating. For comparison purposes, conventional echo time (TE = 2.1 ms) images were acquired simultaneously during each acquisition using a radial " outward-inward" k-space trajectory. 3D percent OE maps were generated from these images. 3D OE maps showing lung signal enhancement were generated successfully in seven subjects (technical failure in one subject). Mean percent signal enhancement was 6.6% ± 1.8%, near the value predicted by theory of 6.3%. No significant enhancement was seen using the conventional echo time data, confirming the importance of UTE for this acquisition strategy. 3D radial UTE MRI shows promise as a method for OE MRI that enables whole-lung coverage and isotropic spatial resolution, in comparison to existing 2D OE methods, which rely on a less time-efficient inversion recovery pulse sequence. These qualities may help OE MRI become a viable low-cost method for 3D imaging of lung function in human subjects.

Citing Articles

Feasibility of dynamic T *-based oxygen-enhanced lung MRI at 3T.

Kim M, Naish J, Needleman S, Tibiletti M, Taylor Y, OConnor J Magn Reson Med. 2023; 91(3):972-986.

PMID: 38013206 PMC: 10952203. DOI: 10.1002/mrm.29914.

Independent component analysis (ICA) applied to dynamic oxygen-enhanced MRI (OE-MRI) for robust functional lung imaging at 3 T.

Needleman S, Kim M, McClelland J, Naish J, Tibiletti M, OConnor J Magn Reson Med. 2023; 91(3):955-971.

PMID: 37984456 PMC: 10952250. DOI: 10.1002/mrm.29912.

Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report.

Hsia C, Bates J, Driehuys B, Fain S, Goldin J, Hoffman E Ann Am Thorac Soc. 2023; 20(2):161-195.

PMID: 36723475 PMC: 9989862. DOI: 10.1513/AnnalsATS.202211-915ST.

Free-Breathing Phase-Resolved Oxygen-Enhanced Pulmonary MRI Based on 3D Stack-of-Stars UTE Sequence.

Xu P, Zhang J, Nan Z, Meersmann T, Wang C Sensors (Basel). 2022; 22(9).

PMID: 35590959 PMC: 9105788. DOI: 10.3390/s22093270.

Self-gated 3D stack-of-spirals UTE pulmonary imaging at 0.55T.

Javed A, Ramasawmy R, OBrien K, Mancini C, Su P, Majeed W Magn Reson Med. 2021; 87(4):1784-1798.

PMID: 34783391 PMC: 8865631. DOI: 10.1002/mrm.29079.

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