"Structure-Function Imaging of Lung Disease Using Ultrashort Echo Time MRI"

Overview

Journal Acad Radiol

Specialty Radiology

Date 2019 Jan 20

PMID 30658930

Citations 20

Authors

Luis Torres

Jeff Kammerman

Andrew D Hahn

Wei Zha

Scott K Nagle

Kevin Johnson

Nathan Sandbo

Keith Meyer

Mark Schiebler

Sean B Fain

Affiliations

Soon will be listed here.

Abstract

Rationale And Objectives: The purpose of this review is to acquaint the reader with recent advances in ultrashort echo time (UTE) magnetic resonance imaging (MRI) of the lung and its implications for pulmonary MRI when used in conjunction with functional MRI technique.

Materials And Methods: We provide an overview of recent technical advances of UTE and explore the advantages of combined structure-function pulmonary imaging in the context of restrictive and obstructive pulmonary diseases such as idiopathic pulmonary fibrosis (IPF) and cystic fibrosis (CF).

Results: UTE MRI clearly shows the lung parenchymal changes due to IPF and CF. The use of UTE MRI, in conjunction with established functional lung MRI in chronic lung diseases, will serve to mitigate the need for computed tomography in children.

Conclusion: Current limitations of UTE MRI include long scan times, poor delineation of thin-walled structures (e.g. cysts and reticulation) due to limited spatial resolution, low signal to noise ratio, and imperfect motion compensation. Despite these limitations, UTE MRI can now be considered as an alternative to multidetector computed tomography for the longitudinal follow-up of the morphological changes from lung diseases in neonates, children, and young adults, particularly as a complement to the unique functional capabilities of MRI.

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