Lung Macrophages "digest" Carbon Nanotubes Using a Superoxide/peroxynitrite Oxidative Pathway

Overview

Journal ACS Nano

Publisher American Chemical Society

Specialty Biotechnology

Date 2014 May 30

PMID 24871084

Citations 39

Authors

Valerian E Kagan

Alexandr A Kapralov

Claudette M St Croix

Simon C Watkins

Elena R Kisin

Gregg P Kotchey

Krishnakumar Balasubramanian

Irina I Vlasova

Jaesok Yu

Kang Kim

Wanji Seo

Rama K Mallampalli

Alexander Star

Anna A Shvedova

Affiliations

Soon will be listed here.

Abstract

In contrast to short-lived neutrophils, macrophages display persistent presence in the lung of animals after pulmonary exposure to carbon nanotubes. While effective in the clearance of bacterial pathogens and injured host cells, the ability of macrophages to "digest" carbonaceous nanoparticles has not been documented. Here, we used chemical, biochemical, and cell and animal models and demonstrated oxidative biodegradation of oxidatively functionalized single-walled carbon nanotubes via superoxide/NO* → peroxynitrite-driven oxidative pathways of activated macrophages facilitating clearance of nanoparticles from the lung.

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