Impaired Clearance and Enhanced Pulmonary Inflammatory/fibrotic Response to Carbon Nanotubes in Myeloperoxidase-deficient Mice

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Apr 6

PMID 22479306

Citations 57

Authors

Anna A Shvedova

Alexandr A Kapralov

Wei Hong Feng

Elena R Kisin

Ashley R Murray

Robert R Mercer

Claudette M St Croix

Megan A Lang

Simon C Watkins

Nagarjun V Konduru

Brett L Allen

Jennifer Conroy

Gregg P Kotchey

Bashir M Mohamed

Aidan D Meade

Yuri Volkov

Alexander Star

Bengt Fadeel

Valerian E Kagan

Affiliations

Soon will be listed here.

Abstract

Advancement of biomedical applications of carbonaceous nanomaterials is hampered by their biopersistence and pro-inflammatory action in vivo. Here, we used myeloperoxidase knockout B6.129X1-MPO (MPO k/o) mice and showed that oxidation and clearance of single walled carbon nanotubes (SWCNT) from the lungs of these animals after pharyngeal aspiration was markedly less effective whereas the inflammatory response was more robust than in wild-type C57Bl/6 mice. Our results provide direct evidence for the participation of MPO - one of the key-orchestrators of inflammatory response - in the in vivo pulmonary oxidative biodegradation of SWCNT and suggest new ways to control the biopersistence of nanomaterials through genetic or pharmacological manipulations.

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