Proteobacteria-specific IgA Regulates Maturation of the Intestinal Microbiota

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2014 Mar 19

PMID 24637807

Citations 136

Authors

Julie Mirpuri

Megan Raetz

Carolyn R Sturge

Cara L Wilhelm

Alicia Benson

Rashmin C Savani

Lora V Hooper

Felix Yarovinsky

Affiliations

Soon will be listed here.

Abstract

The intestinal microbiota changes dynamically from birth to adulthood. In this study we identified γ-Proteobacteria as a dominant phylum present in newborn mice that is suppressed in normal adult microbiota. The transition from a neonatal to a mature microbiota was in part regulated by induction of a γ-Proteobacteria-specific IgA response. Neocolonization experiments in germ-free mice further revealed a dominant Proteobacteria-specific IgA response triggered by the immature microbiota. Finally, a role for B cells in the regulation of microbiota maturation was confirmed in IgA-deficient mice. Mice lacking IgA had persistent intestinal colonization with γ-Proteobacteria that resulted in sustained intestinal inflammation and increased susceptibility to neonatal and adult models of intestinal injury. Collectively, these results identify an IgA-dependent mechanism responsible for the maturation of the intestinal microbiota.

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