Glycerol-derived Reuterin Regulates Human Intestinal Microbiota and Metabolites

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2024 Nov 4

PMID 39493857

Authors

Xi Yang

Wei Liu

Xiaoling Zhang

Minhua Sun

Hongbo Yi

Shenquan Liao

Rong Xiang

Hao Zhang

Qiao Yang

Hirotada Mori

Affiliations

Soon will be listed here.

Abstract

Reuterin, a mixture of different forms of 3-hydroxypropanal (3-HPA), including HPA hydrate and HPA dimer, is an antimicrobial compound converted from glycerol by . Although its antimicrobial function may be related to its interaction with thiol groups, its temperature stability and effect on the gut environment remain unclear. The present study evaluated the antimicrobial effects and activity of reuterin against and . Utilization of a reliable gut microbiome fermentation system revealed that reuterin has a modulatory effect on the gut microbial community. Reuterin treatment completely inhibited H and NH production in the gut and significantly enhanced the synthesis of branched short-chain fatty acids. 16s rRNA sequencing indicated that reuterin promoted the growth of Proteobacteria and Bacteroidetes in the system and significantly modulated gut microbiota composition.

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