Fecal Transplant from Vaginally Seeded Infants Decreases Intraabdominal Adiposity in Mice

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2024 May 14

PMID 38743047

Authors

Sivaranjani Namasivayam

Curtis Tilves

Hua Ding

Shaoguang Wu

Jada C Domingue

Camilo Ruiz-Bedoya

Ankit Shah

Eric Bohrnsen

Benjamin Schwarz

Mickayla Bacorn

Qing Chen

Shira Levy

Maria Gloria Dominguez Bello

Sanjay K Jain

Cynthia L Sears

Noel T Mueller

Suchitra K Hourigan

Affiliations

Soon will be listed here.

Abstract

Exposing C-section infants to the maternal vaginal microbiome, coined "vaginal seeding", partially restores microbial colonization. However, whether vaginal seeding decreases metabolic disease risk is unknown. Therefore, we assessed the effect of vaginal seeding of human infants on adiposity in a murine model. Germ-free mice were colonized with transitional stool from human infants who received vaginal seeding or control (placebo) seeding in a double-blind randomized trial. There was a reduction in intraabdominal adipose tissue (IAAT) volume in male mice that received stool from vaginally seeded infants compared to control infants. Higher levels of isoleucine and lower levels of nucleic acid metabolites were observed in controls and correlated with increased IAAT. This suggests that early changes in the gut microbiome and metabolome caused by vaginal seeding have a positive impact on metabolic health.

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