Discovery of a Cyclopentylamine As an Orally Active Dual NK1 Receptor Antagonist-serotonin Reuptake Transporter Inhibitor
Overview
Overview
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Cyclopentylamine 4 was identified as a potent dual NK1R antagonist-SERT inhibitor. This compound demonstrated significant oral activity in the gerbil forced swimming test, suggesting that dual NK1R antagonists-SERT inhibitors may be useful in treating depression disorders.
Citing Articles
Chen Y, Ying S, Zheng H, Liu Y, Wang Z, Zhang H Sci Rep. 2017; 7(1):15114.
PMID: 29118341 PMC: 5678126. DOI: 10.1038/s41598-017-15483-6.