Novel Serotonin Transporter Regulators: Natural Aristolane- and Nardosinane- Types of Sesquiterpenoids from Nardostachys Chinensis Batal

Overview

Journal Sci Rep

Specialty Science

Date 2017 Nov 10

PMID 29118341

Citations 8

Authors

Ying-Peng Chen

Shu-Song Ying

Hong-Hong Zheng

Yan-Ting Liu

Zhong-Ping Wang

Hu Zhang

Xu Deng

Yi-Jing Wu

Xiu-Mei Gao

Tian-Xiang Li

Yan Zhu

Yan-Tong Xu

Hong-Hua Wu

Affiliations

Soon will be listed here.

Abstract

Serotonin transporter (SERT) is a classic target of drug discovery for neuropsychiatric and digestive disorders, and against those disorders, plants of Nardostachys genus have been valued for centuries in the systems of Traditional Chinese Medicine, Ayurvedic and Unani. Herein, chemical investigation on the roots and rhizomes of Nardostachys chinensis Batal. led to the isolation of forty sesquiterpenoids including six new aristolane-type sesquiterpenoids and six new nardosinane-type sesquiterprenoids. Their structures were elucidated by extensive spectroscopic methods, combined with analyses of circular dichroism and single-crystal X-ray diffraction data. To explore natural product scaffolds with SERT regulating activity, a high-content assay for measurement of SERT function in vitro was conducted to evaluate the SERT regulating properties of these isolates. In conclusion, eleven compounds could be potential natural product scaffolds for developing drug candidates targeting SERT. Among which, kanshone C of aristolane-type sesquiterpenoid inhibited SERT most strongly, while desoxo-nachinol A of nardosinane-type sesquiterpenoid instead enhanced SERT potently.

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