Longitudinal Changes in Calcium and Vitamin D Intakes and Relationship to Bone Mineral Density in a Prospective Population-based Study: the Canadian Multicentre Osteoporosis Study (CaMos)

Overview

Journal J Musculoskelet Neuronal Interact

Specialties Neurology
Orthopedics
Physiology

Date 2013 Dec 3

PMID 24292617

Citations 15

Authors

W Zhou

L Langsetmo

C Berger

S Poliquin

N Kreiger

S I Barr

S M Kaiser

R G Josse

J C Prior

T E Towheed

T Anastassiades

K S Davison

C S Kovacs

D A Hanley

E A Papadimitropoulos

D Goltzman

Affiliations

Soon will be listed here.

Abstract

Objectives: Our objective was to study changes in calcium and vitamin D intakes over time, and their cross-sectional and longitudinal associations with bone mineral density (BMD).

Methods: We followed 9382 women and men aged ≥25 and 899 aged 16-24, for 10 and 2 years respectively.

Results: Calcium and vitamin D intakes increased over time in adults, but decreased in women aged 16-18. The increased intakes in adults were largely attributable to the increased use of calcium and/or vitamin D supplements. Both the percentage of supplement users and average dose among users increased over time. There was nevertheless a high prevalence of calcium and vitamin D intake below the estimated average requirement. At baseline, higher calcium and vitamin D intakes were associated with higher total hip and femoral neck BMD in young men, and cumulatively high levels of calcium and vitamin D intakes over time contributed to better BMD maintenance at lumbar spine and hip sites in adult women.

Conclusions: Although total intakes, particularly of vitamin D, frequently fell below the Institute of Medicine recommendations despite an increase over time in supplement use, we found some positive associations between total calcium and vitamin D intake and bone health.

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References

Lips P, Duong T, Oleksik A, Black D, Cummings S, Cox D . A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial. J Clin Endocrinol Metab. 2001; 86(3):1212-21. DOI: 10.1210/jcem.86.3.7327. View

Berger C, Greene-Finestone L, Langsetmo L, Kreiger N, Joseph L, Kovacs C . Temporal trends and determinants of longitudinal change in 25-hydroxyvitamin D and parathyroid hormone levels. J Bone Miner Res. 2012; 27(6):1381-9. PMC: 5101062. DOI: 10.1002/jbmr.1587. View

Vatanparast H, Calvo M, Green T, Whiting S . Despite mandatory fortification of staple foods, vitamin D intakes of Canadian children and adults are inadequate. J Steroid Biochem Mol Biol. 2010; 121(1-2):301-3. DOI: 10.1016/j.jsbmb.2010.03.079. View

Garland C, Gorham E, Mohr S, Garland F . Vitamin D for cancer prevention: global perspective. Ann Epidemiol. 2009; 19(7):468-83. DOI: 10.1016/j.annepidem.2009.03.021. View

Shah S, Carey I, Harris T, DeWilde S, Cook D . Calcium supplementation, cardiovascular disease and mortality in older women. Pharmacoepidemiol Drug Saf. 2009; 19(1):59-64. DOI: 10.1002/pds.1859. View

Bolland M, Grey A, Avenell A, Gamble G, Reid I . Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. 2011; 342:d2040. PMC: 3079822. DOI: 10.1136/bmj.d2040. View

Komulainen M, Kroger H, Tuppurainen M, Heikkinen A, Alhava E, Honkanen R . Prevention of femoral and lumbar bone loss with hormone replacement therapy and vitamin D3 in early postmenopausal women: a population-based 5-year randomized trial. J Clin Endocrinol Metab. 1999; 84(2):546-52. DOI: 10.1210/jcem.84.2.5496. View

Boonen S, Lips P, Bouillon R, Bischoff-Ferrari H, Vanderschueren D, Haentjens P . Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab. 2007; 92(4):1415-23. DOI: 10.1210/jc.2006-1404. View

Prentice R, Pettinger M, Jackson R, Wactawski-Wende J, LaCroix A, Anderson G . Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study. Osteoporos Int. 2012; 24(2):567-80. PMC: 3557387. DOI: 10.1007/s00198-012-2224-2. View

10.

Power M, Heaney R, Kalkwarf H, Pitkin R, Repke J, Tsang R . The role of calcium in health and disease. Am J Obstet Gynecol. 1999; 181(6):1560-9. DOI: 10.1016/s0002-9378(99)70404-7. View

11.

Lu Y, Fuerst T, Hui S, Genant H . Standardization of bone mineral density at femoral neck, trochanter and Ward's triangle. Osteoporos Int. 2001; 12(6):438-44. DOI: 10.1007/s001980170087. View

12.

Konradsen S, Ag H, Lindberg F, Hexeberg S, Jorde R . Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr. 2008; 47(2):87-91. DOI: 10.1007/s00394-008-0700-4. View

13.

Roth D . Bones and beyond: an update on the role of vitamin D in child and adolescent health in Canada. Appl Physiol Nutr Metab. 2007; 32(4):770-7. DOI: 10.1139/H07-055. View

14.

Pentti K, Tuppurainen M, Honkanen R, Sandini L, Kroger H, Alhava E . Use of calcium supplements and the risk of coronary heart disease in 52-62-year-old women: The Kuopio Osteoporosis Risk Factor and Prevention Study. Maturitas. 2009; 63(1):73-8. DOI: 10.1016/j.maturitas.2009.03.006. View

15.

Bailey R, Dodd K, Goldman J, Gahche J, Dwyer J, Moshfegh A . Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr. 2010; 140(4):817-22. PMC: 2838624. DOI: 10.3945/jn.109.118539. View

16.

Poliquin S, Joseph L, Gray-Donald K . Calcium and vitamin D intakes in an adult Canadian population. Can J Diet Pract Res. 2009; 70(1):21-7. DOI: 10.3148/70.1.2009.21. View

17.

Berger C, Goltzman D, Langsetmo L, Joseph L, Jackson S, Kreiger N . Peak bone mass from longitudinal data: implications for the prevalence, pathophysiology, and diagnosis of osteoporosis. J Bone Miner Res. 2010; 25(9):1948-57. PMC: 5101070. DOI: 10.1002/jbmr.95. View

18.

Fan B, Lu Y, Genant H, Fuerst T, Shepherd J . Does standardized BMD still remove differences between Hologic and GE-Lunar state-of-the-art DXA systems?. Osteoporos Int. 2009; 21(7):1227-36. PMC: 2906746. DOI: 10.1007/s00198-009-1062-3. View

19.

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

20.

Genant H, Grampp S, Gluer C, Faulkner K, Jergas M, Engelke K . Universal standardization for dual x-ray absorptiometry: patient and phantom cross-calibration results. J Bone Miner Res. 1994; 9(10):1503-14. DOI: 10.1002/jbmr.5650091002. View