Peak Bone Mass Formation: Modern View of the Problem
Overview
Affiliations
Peak bone mass is the amount of bone tissue that is formed when a stable skeletal state is achieved at a young age. To date, there are no established peak bone mass standards nor clear data on the age at which peak bone mass occurs. At the same time, the level of peak bone mass at a young age is an important predictor of the onset of primary osteoporosis. The purpose of this review is to analyze the results of studies of levels of peak bone mass in general, the age of its onset, as well as factors influencing its formation. Factors such as hormonal levels, body composition, physical activity, nutrition, heredity, smoking, lifestyle, prenatal predictors, intestinal microbiota, and vitamin and micronutrient status were considered, and a comprehensive scheme of the influence of these factors on the level of peak bone mass was created. Determining the standards and timing of the formation of peak bone mass, and the factors affecting it, will help in the development of measures to prevent its shortage and the consequent prevention of osteoporosis and concomitant diseases.
Association Between the Bone Density of Alveolar and General Skeletal Bones in the Young.
Sugino N, Kuroiwa H, Osanai H, Yamada S, Dewake N, Suzuki S Cureus. 2025; 17(2):e78643.
PMID: 40065861 PMC: 11891509. DOI: 10.7759/cureus.78643.
Valeeva D, Akhiiarova K, Minniakhmetov I, Mokrysheva N, Khusainova R, Tyurin A Diagnostics (Basel). 2025; 15(3).
PMID: 39941180 PMC: 11817190. DOI: 10.3390/diagnostics15030250.
Hypomethylation of the Gene Is a New Potential Biomarker of Primary Osteoporosis in Men and Women.
Yalaev B, Tyurin A, Akhiiarova K, Khusainova R Int J Mol Sci. 2024; 25(13).
PMID: 39000419 PMC: 11242095. DOI: 10.3390/ijms25137312.
Xiao P, Wang Z, Lu Z, Liu S, Huang C, Xu Y Lipids Health Dis. 2024; 23(1):148.
PMID: 38762471 PMC: 11102129. DOI: 10.1186/s12944-024-02145-6.