Effect of Calcium and Vitamin D Supplementation with and Without Collagen Peptides on Bone Turnover in Postmenopausal Women with Osteopenia

Overview

Journal J Musculoskelet Neuronal Interact

Specialties Neurology
Orthopedics
Physiology

Date 2020 Mar 6

PMID 32131366

Citations 5

Authors

Chrysoula Argyrou

Efthymia Karlafti

Kalliopi Lampropoulou-Adamidou

Symeon Tournis

Konstantinos Makris

George Trovas

Ismene Dontas

Ioannis K Triantafyllopoulos

Affiliations

Soon will be listed here.

Abstract

Objectives: Collagen peptides (CPs) seem to exert beneficial effects on bone and may have a role as a treatment option. In the present randomized prospective study, we aimed to examine the efficacy, as expressed by changes in P1NP and CTX, and the tolerability of 3-month supplementation of calcium, vitamin D with or without bioactive CPs in postmenopausal women with osteopenia.

Methods: Fifty-one female, postmenopausal women with osteopenia were allocated to two groups: Group A received a sachet containing 5 g CPs, 3.6 g calcium lactate (equivalent to 500 mg of elemental calcium) and 400 IU vitamin D3 and group B received a chewable tablet containing 1.25 g calcium carbonate (equivalent to 500 mg of elemental calcium) and 400 IU vitamin D3 daily.

Results: In group A, the P1NP levels significantly decreased by 13.1% (p<0.001) and CTX levels decreased by 11.4% (p=0.058) within 3 months of supplementation. In group B, P1NP and CTX did not change. Group A presented better compliance in comparison to group B and no adverse events contrary to group B.

Conclusions: These findings may reflect the reduction of the increased bone turnover in postmenopausal women with the use of calcium, vitamin D and CPs supplements. The addition of CPs in a calcium and vitamin D supplement may enhance its already known positive effect on bone metabolism. Clinical Trial ID: NCT03999775.

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