Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-fat, High-sugar Diet

Overview

Journal Cell Metab

Publisher Cell Press

Specialties Cell Biology
Endocrinology

Date 2013 Oct 8

PMID 24093677

Citations 126

Authors

Yolanda Jimenez-Gomez

Julie A Mattison

Kevin J Pearson

Alejandro Martin-Montalvo

Hector H Palacios

Alex M Sossong

Theresa M Ward

Caitlin M Younts

Kaitlyn Lewis

Joanne S Allard

Dan L Longo

Jonathan P Belman

Maria M Malagon

Placido Navas

Mitesh Sanghvi

Ruin Moaddel

Edward M Tilmont

Richard L Herbert

Christopher H Morrell

Josephine M Egan

Joseph A Baur

Luigi Ferrucci

Jonathan S Bogan

Michel Bernier

Rafael de Cabo

Affiliations

Soon will be listed here.

Abstract

Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-κB activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS ± resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

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