A Novel Benzazepinone Sodium Channel Blocker with Oral Efficacy in a Rat Model of Neuropathic Pain

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2013 May 9

PMID 23652221

Citations 6

Authors

Scott B Hoyt

Clare London

Catherine Abbadie

John P Felix

Maria L Garcia

Nina Jochnowitz

Bindhu V Karanam

Xiaohua Li

Kathryn A Lyons

Erin McGowan

Birgit T Priest

McHardy M Smith

Vivien A Warren

Brande S Thomas-Fowlkes

Gregory J Kaczorowski

Joseph L Duffy

Affiliations

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Abstract

A series of benzazepinones were synthesized and evaluated for block of Nav1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neuropathic pain.

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