Impact of Age on Markers of HIV-1 Disease

Overview

Journal Future Virol

Specialty Microbiology

Date 2013 Apr 19

PMID 23596462

Citations 10

Authors

Vanessa Pirrone

David J Libon

Christian Sell

Chad A Lerner

Michael R Nonnemacher

Brian Wigdahl

Affiliations

Soon will be listed here.

Abstract

Aging is a complicated process characterized by a progressive loss of homeostasis, which results in an increased vulnerability to multiple diseases. HIV-1-infected patients demonstrate a premature aging phenotype and develop certain age-related diseases earlier in their lifespan than what is seen in the general population. Age-related comorbidities may include the development of bone disease, metabolic disorders, neurologic impairment and immunosenescence. Age also appears to have an effect on traditional markers of HIV-1 disease progression, including CD4 T-cell count and viral load. These effects are not only a consequence of HIV-1 infection, but in many cases, are also linked to antiretroviral therapy. This review summarizes the complex interplay between HIV-1 infection and aging, and the impact that aging has on markers of HIV-1 disease.

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