The Comings and Goings of PARP-1 in Response to DNA Damage

Overview

Journal DNA Repair (Amst)

Publisher Elsevier

Specialties Biochemistry
Molecular Biology

Date 2018 Sep 5

PMID 30177435

Citations 163

Authors

John M Pascal

Affiliations

Soon will be listed here.

Abstract

Poly(ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA damage response, acting as a first responder that detects DNA strand breaks, and contributes to repair pathway choice and the efficiency of repair through modulation of chromatin structure and through interaction with and modification of a multitude of DNA repair factors. This perspective summarizes our knowledge of PARP-1 involvement in DNA repair pathways, and highlights recent structural and functional data regarding the activation of PARP-1 upon detecting DNA damage, and the release and trapping of PARP-1 at sites of DNA damage.

Citing Articles

HPF1 Regulates Pol β Efficiency in Nucleosomes via the Modulation of Total Poly(ADP-Ribose) Synthesis.

Kutuzov M, Sayfullina D, Belousova E, Lavrik O Int J Mol Sci. 2025; 26(5).

PMID: 40076422 PMC: 11898694. DOI: 10.3390/ijms26051794.

Microrna-342 inhibits hepatocellular carcinoma cell proliferation and promotes apoptosis through the FOXP1/MYCBP Signaling Axis.

Zhang Y, Da Yang G, Chen Q, Zeng J, Cao Y Toxicol Res (Camb). 2024; 13(6):tfae149.

PMID: 39698396 PMC: 11649998. DOI: 10.1093/toxres/tfae149.

Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition.

Shanmugam N, Chatterjee S, Cisneros G bioRxiv. 2024; .

PMID: 39605557 PMC: 11601374. DOI: 10.1101/2024.11.13.623412.

Olaparib Enhances the Efficacy of Third-Generation Oncolytic Adenoviruses Against Glioblastoma by Modulating DNA Damage Response and p66shc-Induced Apoptosis.

Liu Y, Fang S, Wang P, Zhang J, Liu F CNS Neurosci Ther. 2024; 30(11):e70124.

PMID: 39552450 PMC: 11570871. DOI: 10.1111/cns.70124.

Interaction of RECQL4 with poly(ADP-ribose) is critical for the DNA double-strand break response in human cells.

Shin S, Kim D, Kim H, Cho W, Kim G, Lee J FEBS Open Bio. 2024; 15(1):140-150.

PMID: 39462683 PMC: 11705483. DOI: 10.1002/2211-5463.13917.

References

Dantzer F, de La Rubia G, Hostomsky Z, de Murcia G, Schreiber V . Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. Biochemistry. 2000; 39(25):7559-69. DOI: 10.1021/bi0003442. View

Smith S, de Lange T . Tankyrase promotes telomere elongation in human cells. Curr Biol. 2000; 10(20):1299-302. DOI: 10.1016/s0960-9822(00)00752-1. View

Lavrik O, Prasad R, Sobol R, Horton J, Ackerman E, Wilson S . Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair. J Biol Chem. 2001; 276(27):25541-8. DOI: 10.1074/jbc.M102125200. View

Prasad R, Lavrik O, Kim S, Kedar P, Yang X, Vande Berg B . DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis. J Biol Chem. 2001; 276(35):32411-4. DOI: 10.1074/jbc.C100292200. View

Leppard J, Dong Z, Mackey Z, Tomkinson A . Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair. Mol Cell Biol. 2003; 23(16):5919-27. PMC: 166336. DOI: 10.1128/MCB.23.16.5919-5927.2003. View

El-Khamisy S, Masutani M, Suzuki H, Caldecott K . A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res. 2003; 31(19):5526-33. PMC: 206461. DOI: 10.1093/nar/gkg761. View

Yang Y, Cortes U, Patnaik S, Jasin M, Wang Z . Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene. 2004; 23(21):3872-82. DOI: 10.1038/sj.onc.1207491. View

Satoh M, Lindahl T . Role of poly(ADP-ribose) formation in DNA repair. Nature. 1992; 356(6367):356-8. DOI: 10.1038/356356a0. View

Bryant H, Schultz N, Thomas H, Parker K, Flower D, Lopez E . Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005; 434(7035):913-7. DOI: 10.1038/nature03443. View

10.

Farmer H, McCabe N, Lord C, Tutt A, Johnson D, Richardson T . Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005; 434(7035):917-21. DOI: 10.1038/nature03445. View

11.

Chang P, Coughlin M, Mitchison T . Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol. 2005; 7(11):1133-9. DOI: 10.1038/ncb1322. View

12.

Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, Schreiber V . Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J. 2006; 25(6):1305-14. PMC: 1422167. DOI: 10.1038/sj.emboj.7601015. View

13.

Ahel I, Rass U, El-Khamisy S, Katyal S, Clements P, McKinnon P . The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature. 2006; 443(7112):713-6. DOI: 10.1038/nature05164. View

14.

Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H . PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 2006; 34(21):6170-82. PMC: 1693894. DOI: 10.1093/nar/gkl840. View

15.

Fisher A, Hochegger H, Takeda S, Caldecott K . Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Mol Cell Biol. 2007; 27(15):5597-605. PMC: 1952076. DOI: 10.1128/MCB.02248-06. View

16.

Hassa P, Hottiger M . The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci. 2007; 13:3046-82. DOI: 10.2741/2909. View

17.

Langelier M, Servent K, Rogers E, Pascal J . A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation. J Biol Chem. 2007; 283(7):4105-14. DOI: 10.1074/jbc.M708558200. View

18.

Bryant H, Petermann E, Schultz N, Jemth A, Loseva O, Issaeva N . PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J. 2009; 28(17):2601-15. PMC: 2738702. DOI: 10.1038/emboj.2009.206. View

19.

Ahel D, Horejsi Z, Wiechens N, Polo S, Garcia-Wilson E, Ahel I . Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science. 2009; 325(5945):1240-3. PMC: 3443743. DOI: 10.1126/science.1177321. View

20.

Gottschalk A, Timinszky G, Kong S, Jin J, Cai Y, Swanson S . Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc Natl Acad Sci U S A. 2009; 106(33):13770-4. PMC: 2722505. DOI: 10.1073/pnas.0906920106. View