Verification of a Computational Cardiovascular System Model Comparing the Hemodynamics of a Continuous Flow to a Synchronous Valveless Pulsatile Flow Left Ventricular Assist Device

Overview

Journal ASAIO J

Specialty General Surgery

Date 2013 Feb 27

PMID 23438771

Citations 8

Authors

Jeffrey R Gohean

Mitchell J George

Thomas D Pate

Mark Kurusz

Raul G Longoria

Richard W Smalling

Affiliations

Soon will be listed here.

Abstract

The purpose of this investigation is to use a computational model to compare a synchronized valveless pulsatile left ventricular assist device with continuous flow left ventricular assist devices at the same level of device flow, and to verify the model with in vivo porcine data. A dynamic system model of the human cardiovascular system was developed to simulate the support of a healthy or failing native heart from a continuous flow left ventricular assist device or a synchronous pulsatile valveless dual-piston positive displacement pump. These results were compared with measurements made during in vivo porcine experiments. Results from the simulation model and from the in vivo counterpart show that the pulsatile pump provides higher cardiac output, left ventricular unloading, cardiac pulsatility, and aortic valve flow as compared with the continuous flow model at the same level of support. The dynamic system model developed for this investigation can effectively simulate human cardiovascular support by a synchronous pulsatile or continuous flow ventricular assist device.

Citing Articles

Parameter Identification of Cardiovascular System Model Used for Left Ventricular Assist Device Algorithms.

Pawar S, Rapp E, Gohean J, Longoria R J Eng Sci Med Diagn Ther. 2022; 5(1):011006.

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Scaling the Low-Shear Pulsatile TORVAD for Pediatric Heart Failure.

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