Eosinophils and Resistance to Trichinella Spiralis

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1977 Mar 1

PMID 233913

Citations 37

Authors

D I Grove

A A Mahmoud

K S Warren

Affiliations

Soon will be listed here.

Abstract

Mice infected with Trichinella spiralis were depleted of eosinophils by repeated administration of rabbit anti-mouse eosinophil serum. There was no effect on the spontaneous expulsion of adult worms from the small intestines, but the numbers of larvae in the muscles were almost doubled. It is concluded that eosinophils contribute to resistance to the systemic phase of trichinosis.

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References

Campbell W . IMMUNIZING EFFECT OF ENTERAL AND ENTERAL-PARENTERAL INFECTIONS OF TRICHINELLA SPIRALIS IN MICE. J Parasitol. 1965; 51:185-94. View

Warren K, Karp R, Pelley R, Mahmoud A . The eosinophil stimulation promoter test in murine and human Trichinella spiralis infection. J Infect Dis. 1976; 134(3):277-80. DOI: 10.1093/infdis/134.3.277. View

Grove D, Warren K . Effects on murine trichinosis of niridazole, a suppressant of cellular but not humoral immunological responses. Ann Trop Med Parasitol. 1976; 70(4):449-53. DOI: 10.1080/00034983.1976.11687146. View

Mahmoud A, Warren K, Boros D . Production of a rabbit antimouse eosinophil serum with no cross-reactivity to neutrophils. J Exp Med. 1973; 137(6):1526-31. PMC: 2139341. DOI: 10.1084/jem.137.6.1526. View

LARSH Jr J . Allergic inflammation as a hypothesis for the expulsion of worms from tissues: a review. Exp Parasitol. 1975; 37(2):251-66. DOI: 10.1016/0014-4894(75)90077-6. View