Nanotechnology: Toxicologic Pathology

Overview

Journal Toxicol Pathol

Publisher Sage Publications

Date 2013 Feb 8

PMID 23389777

Citations 16

Authors

Ann F Hubbs

Linda M Sargent

Dale W Porter

Tina M Sager

Bean T Chen

David G Frazer

Vincent Castranova

Krishnan Sriram

Timothy R Nurkiewicz

Steven H Reynolds

Lori A Battelli

Diane Schwegler-Berry

Walter McKinney

Kara L Fluharty

Robert R Mercer

Affiliations

Soon will be listed here.

Abstract

Nanotechnology involves technology, science, and engineering in dimensions less than 100 nm. A virtually infinite number of potential nanoscale products can be produced from many different molecules and their combinations. The exponentially increasing number of nanoscale products will solve critical needs in engineering, science, and medicine. However, the virtually infinite number of potential nanotechnology products is a challenge for toxicologic pathologists. Because of their size, nanoparticulates can have therapeutic and toxic effects distinct from micron-sized particulates of the same composition. In the nanoscale, distinct intercellular and intracellular translocation pathways may provide a different distribution than that obtained by micron-sized particulates. Nanoparticulates interact with subcellular structures including microtubules, actin filaments, centrosomes, and chromatin; interactions that may be facilitated in the nanoscale. Features that distinguish nanoparticulates from fine particulates include increased surface area per unit mass and quantum effects. In addition, some nanotechnology products, including the fullerenes, have a novel and reactive surface. Augmented microscopic procedures including enhanced dark-field imaging, immunofluorescence, field-emission scanning electron microscopy, transmission electron microscopy, and confocal microscopy are useful when evaluating nanoparticulate toxicologic pathology. Thus, the pathology assessment is facilitated by understanding the unique features at the nanoscale and the tools that can assist in evaluating nanotoxicology studies.

Citing Articles

Developing a Solution for Nasal and Olfactory Transport of Nanomaterials.

OConnell R, Dodd T, Clingerman S, Fluharty K, Coyle J, Stueckle T Toxicol Pathol. 2022; 50(3):329-343.

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Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue Engineering, Antimicrobial, and Agro-Food Applications.

Harish V, Tewari D, Gaur M, Yadav A, Swaroop S, Bechelany M Nanomaterials (Basel). 2022; 12(3).

PMID: 35159802 PMC: 8839643. DOI: 10.3390/nano12030457.

Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects.

Krajnak K, Kan H, Russ K, McKinney W, Waugh S, Zheng W Toxicol Appl Pharmacol. 2020; 406:115242.

PMID: 32931794 PMC: 7673239. DOI: 10.1016/j.taap.2020.115242.

Nanoparticles: An Experimental Study of Zinc Nanoparticles Toxicity on Marine Crustaceans. General Overview on the Health Implications in Humans.

Vimercati L, Cavone D, Caputi A, De Maria L, Tria M, Prato E Front Public Health. 2020; 8:192.

PMID: 32509719 PMC: 7253631. DOI: 10.3389/fpubh.2020.00192.

The Relationship between Exposure to Lead-Containing Welding Fumes and the Levels of Reproductive Hormones.

Dehghan S, Mehrifar Y, Ardalan A Ann Glob Health. 2019; 85(1):125.

PMID: 31673512 PMC: 6798783. DOI: 10.5334/aogh.2617.

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