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Linda M Sargent

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Articles 24
Citations 562
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Recent Articles
1.
Porter D, Orandle M, Hubbs A, Staska L, Lowry D, Kashon M, et al.
Nanotoxicology . 2024 Feb; 18(1):69-86. PMID: 38420937
In the lung, carcinogenesis is a multi-stage process that includes initiation by a genotoxic agent, promotion that expands the population of cells with damaged DNA to form a tumor, and...
2.
Fraser K, Kodali V, Yanamala N, Birch M, Cena L, Casuccio G, et al.
Part Fibre Toxicol . 2020 Dec; 17(1):62. PMID: 33287860
Background: Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxicity to...
3.
Siegrist K, Reynolds S, Porter D, Mercer R, Bauer A, Lowry D, et al.
Part Fibre Toxicol . 2019 Oct; 16(1):36. PMID: 31590690
Background: The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the...
4.
Duke K, Thompson E, Ihrie M, Taylor-Just A, Ash E, Shipkowski K, et al.
Nanotoxicology . 2018 Oct; 12(9):975-991. PMID: 30317900
The fiber-like shape of multi-walled carbon nanotubes (MWCNTs) is reminiscent of asbestos, suggesting they pose similar health hazards when inhaled, including pulmonary fibrosis and mesothelioma. Mice deficient in the tumor...
5.
Davis T, Patberg S, Sargent L, Stefaniak A, Holland L
Anal Chim Acta . 2018 Jun; 1027:149-157. PMID: 29866264
Surface oxidation improves the dispersion of carbon nanotubes in aqueous solutions and plays a key role in the development of biosensors, electrochemical detectors and polymer composites. Accurate characterization of the...
6.
Bishop L, Cena L, Orandle M, Yanamala N, Dahm M, Birch M, et al.
ACS Nano . 2017 Aug; 11(9):8849-8863. PMID: 28759202
Pulmonary toxicity studies on carbon nanotubes focus primarily on as-produced materials and rarely are guided by a life cycle perspective or integration with exposure assessment. Understanding toxicity beyond the as-produced,...
7.
Hubbs A, Fluharty K, Edwards R, Barnabei J, Grantham J, Palmer S, et al.
Am J Pathol . 2016 Sep; 186(11):2887-2908. PMID: 27643531
Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl...
8.
Kuempel E, Jaurand M, Moller P, Morimoto Y, Kobayashi N, Pinkerton K, et al.
Crit Rev Toxicol . 2016 Aug; 47(1):1-58. PMID: 27537422
In an evaluation of carbon nanotubes (CNTs) for the IARC Monograph 111, the Mechanisms Subgroup was tasked with assessing the strength of evidence on the potential carcinogenicity of CNTs in...
9.
Dong C, Eldawud R, Sargent L, Kashon M, Lowry D, Rojanasakul Y, et al.
J Mater Chem B . 2015 Jul; 3:3983-3992. PMID: 26146559
The toxicity of engineered nanomaterials in biological systems depends on both the nanomaterial properties and the exposure duration. Herein we used a multi-tier strategy to investigate the relationship between user-characterized...
10.
Snyder-Talkington B, Dong C, Sargent L, Porter D, Staska L, Hubbs A, et al.
J Appl Toxicol . 2015 May; 36(1):161-74. PMID: 25926378
Inhalation exposure to multi-walled carbon nanotubes (MWCNT) in mice results in inflammation, fibrosis and the promotion of lung adenocarcinoma; however, the molecular basis behind these pathologies is unknown. This study...