Mechanisms of Chylomicron Uptake into Lacteals

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2010 Oct 22

PMID 20961306

Citations 51

Authors

J Brandon Dixon

Affiliations

Soon will be listed here.

Abstract

Right from birth, the lymphatics play a crucial role in dietary functions. A majority of the lipid absorbed from the newborn's lipid-rich diet enters the blood circulation through the lymphatic system, which transports triglyceride-loaded particles known as chylomicrons from the villi of the small intestine to the venous circulation near the heart. In light of the significance of this role, as well as the fact that lipid transport from the gut was one of the earliest discovered functions of the lymphatic vasculature, it is surprising that so little is known about how chylomicrons initially gain access to the lymphatic vessel. This review will focus on the current mechanisms thought to be important in this process and highlight important questions that need to be answered in the future.

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References

PALAY S, KARLIN L . An electron microscopic study of the intestinal villus. II. The pathway of fat absorption. J Biophys Biochem Cytol. 1959; 5(3):373-84. PMC: 2224670. DOI: 10.1083/jcb.5.3.373. View

Song L, Kim C, Maslov K, Shung K, Wang L . High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array. Med Phys. 2009; 36(8):3724-9. PMC: 2724177. DOI: 10.1118/1.3168598. View

Collan Y, Kalima T . The lymphatic pump of the intestinal villus of the rat. Scand J Gastroenterol. 1970; 5(3):187-96. View

Trzewik J, Mallipattu S, Artmann G, DeLano F, Schmid-Schonbein G . Evidence for a second valve system in lymphatics: endothelial microvalves. FASEB J. 2001; 15(10):1711-7. DOI: 10.1096/fj.01-0067com. View

Barrowman J . Physiology of the gastro-intestinal lymphatic system. Monogr Physiol Soc. 1978; (33):ix-xii, 1-312. View

Tytgat G, RUBIN C, Saunders D . Synthesis and transport of lipoprotein particles by intestinal absorptive cells in man. J Clin Invest. 1971; 50(10):2065-78. PMC: 292140. DOI: 10.1172/JCI106700. View

Hargens A, ZWEIFACH B . Contractile stimuli in collecting lymph vessels. Am J Physiol. 1977; 233(1):H57-65. DOI: 10.1152/ajpheart.1977.233.1.H57. View

Gashev A, Davis M, Zawieja D . Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct. J Physiol. 2002; 540(Pt 3):1023-37. PMC: 2290276. DOI: 10.1113/jphysiol.2001.016642. View

Azzali G, Vitale M, Arcari M . Ultrastructure of absorbing peripheral lymphatic vessel (ALPA) in guinea pig Peyer's patches. Microvasc Res. 2002; 64(2):289-301. DOI: 10.1006/mvre.2002.2428. View

10.

Backhed F, Crawford P, ODonnell D, Gordon J . Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor. Proc Natl Acad Sci U S A. 2007; 104(2):606-11. PMC: 1761863. DOI: 10.1073/pnas.0605957104. View

11.

Papp M, Rohlich P, Rusznyak I, Toro I . An electron microscopic study of the central lacteal in the intestinal villus of the cat. Z Zellforsch Mikrosk Anat. 1962; 57:475-86. View

12.

Casley-Smith J . AN ELECTRON MICROSCOPIC STUDY OF INJURED AND ABNORMALLY PERMEABLE LYMPATICS. Ann N Y Acad Sci. 1964; 116:803-30. DOI: 10.1111/j.1749-6632.1964.tb52547.x. View

13.

Trevaskis N, Shackleford D, Charman W, Edwards G, Gardin A, Appel-Dingemanse S . Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism. Pharm Res. 2009; 26(6):1486-95. DOI: 10.1007/s11095-009-9860-z. View

14.

Dixon J, Raghunathan S, Swartz M . A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics. Biotechnol Bioeng. 2009; 103(6):1224-35. PMC: 3132564. DOI: 10.1002/bit.22337. View

15.

Azzali G . The passage of macrophage and lymphocytes from the interstitium across the lymphatic endothelium of rat lacteals. Cell Tissue Res. 1990; 262(1):191-3. DOI: 10.1007/BF00327761. View

16.

FLOREY H . Observations on the contractility of lacteals: Part I. J Physiol. 1927; 62(3):267-72. PMC: 1514841. DOI: 10.1113/jphysiol.1927.sp002357. View

17.

Harvey N, Srinivasan R, Dillard M, Johnson N, Witte M, Boyd K . Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet. 2005; 37(10):1072-81. DOI: 10.1038/ng1642. View

18.

BENOIT J, Zawieja D, Goodman A, Granger H . Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress. Am J Physiol. 1989; 257(6 Pt 2):H2059-69. DOI: 10.1152/ajpheart.1989.257.6.H2059. View

19.

RUBIN C . Electron microscopic studies of triglyceride absorption in man. Gastroenterology. 1966; 50(1):65-77. View

20.

Mellor R, Stanton A, Azarbod P, Sherman M, Levick J, Mortimer P . Enhanced cutaneous lymphatic network in the forearms of women with postmastectomy oedema. J Vasc Res. 2001; 37(6):501-12. DOI: 10.1159/000054083. View