Regulation of AID, the B-cell Genome Mutator

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2013 Jan 12

PMID 23307864

Citations 74

Authors

Celia Keim

David Kazadi

Gerson Rothschild

Uttiya Basu

Affiliations

Soon will be listed here.

Abstract

The mechanisms by which B cells somatically engineer their genomes to generate the vast diversity of antibodies required to challenge the nearly infinite number of antigens that immune systems encounter are of tremendous clinical and academic interest. The DNA cytidine deaminase activation-induced deaminase (AID) catalyzes two of these mechanisms: class switch recombination (CSR) and somatic hypermutation (SHM). Recent discoveries indicate a significant promiscuous targeting of this B-cell mutator enzyme genome-wide. Here we discuss the various regulatory elements that control AID activity and prevent AID from inducing genomic instability and thereby initiating oncogenesis.

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