Mutation Profiles of Diffuse Large B-cell Lymphoma Transformation of Splenic B-cell Lymphoma/leukemia, Unclassifiable on Whole-exome Sequencing

Overview

Journal EJHaem

Specialty Hematology

Date 2022 Jul 18

PMID 35845190

Authors

Shuhei Kurosawa

Takashi Toya

Daichi Sadato

Tsunekazu Hishima

Chizuko Hirama

Yuho Najima

Takeshi Kobayashi

Kyoko Haraguchi

Yoshiki Okuyama

Keisuke Oboki

Hironori Harada

Hisashi Sakamaki

Kazuteru Ohashi

Yuka Harada

Noriko Doki

Affiliations

Soon will be listed here.

Abstract

A 58-year-old male was diagnosed with splenic B-cell lymphoma/leukemia, unclassifiable (SPLL-U). The lymphoma transformed into diffuse large B-cell lymphoma (DLBCL), and multidrug chemotherapy and autologous stem cell transplantation achieved complete remission. Two years later, the lymphoma relapsed as SPLL-U. Serial whole-exome sequencing indicated that the mutation profiles were similar between the onset and relapsed samples while those in DLBCL were partially distinctive, which was in line with the clinical course. Hierarchical clustering revealed that an IGLL5 mutation was the founder mutation proceeding the development of the diseases and suggested that KRAS and other mutations might contribute to the transformation.

Citing Articles

Dynamic monitoring of circulating tumor DNA reveals outcomes and genomic alterations in patients with relapsed or refractory large B-cell lymphoma undergoing CAR T-cell therapy.

Zou H, Liu W, Wang X, Wang Y, Wang C, Qiu C J Immunother Cancer. 2024; 12(3).

PMID: 38443094 PMC: 11146396. DOI: 10.1136/jitc-2023-008450.

Mutation profiles of diffuse large B-cell lymphoma transformation of splenic B-cell lymphoma/leukemia, unclassifiable on whole-exome sequencing.

Kurosawa S, Toya T, Sadato D, Hishima T, Hirama C, Najima Y EJHaem. 2022; 2(4):854-860.

PMID: 35845190 PMC: 9175768. DOI: 10.1002/jha2.315.

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Kurosawa S, Toya T, Sadato D, Hishima T, Hirama C, Najima Y . Mutation profiles of diffuse large B-cell lymphoma transformation of splenic B-cell lymphoma/leukemia, unclassifiable on whole-exome sequencing. EJHaem. 2022; 2(4):854-860. PMC: 9175768. DOI: 10.1002/jha2.315. View