Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2022 Dec 23

PMID 36558971

Authors

Lin Zhou

He-Ping Chen

Xinyang Li

Ji-Kai Liu

Affiliations

Soon will be listed here.

Abstract

Two triterpenes, ganoaustralins A () and B (), featuring unprecedented 6/6/6/5/6 scaffolds were isolated from the fruiting bodies of the mushroom . The structures were determined by extensive NMR and HRESIMS spectroscopic analysis. The absolute configuration of the C-25 in ganoaustralin A was assigned by the phenylglycine methyl ester (PGME) method. The relative and absolute configurations of the polycyclic backbones were determined by NMR and ECD calculations, respectively. The plausible biosynthetic pathways of ganoaustralins A and B were proposed. Ganoaustralin B showed weak inhibition against -secretase 1.

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