JNK Expression by Macrophages Promotes Obesity-induced Insulin Resistance and Inflammation

Overview

Journal Science

Specialty Science

Date 2012 Dec 11

PMID 23223452

Citations 325

Authors

Myoung Sook Han

Dae Young Jung

Caroline Morel

Saquib A Lakhani

Jason K Kim

Richard A Flavell

Roger J Davis

Affiliations

Soon will be listed here.

Abstract

The cJun NH(2)-terminal kinase (JNK) signaling pathway contributes to inflammation and plays a key role in the metabolic response to obesity, including insulin resistance. Macrophages are implicated in this process. To test the role of JNK, we established mice with selective JNK deficiency in macrophages. We report that feeding a high-fat diet to control and JNK-deficient mice caused similar obesity, but only mice with JNK-deficient macrophages remained insulin-sensitive. The protection of mice with macrophage-specific JNK deficiency against insulin resistance was associated with reduced tissue infiltration by macrophages. Immunophenotyping demonstrated that JNK was required for pro-inflammatory macrophage polarization. These studies demonstrate that JNK in macrophages is required for the establishment of obesity-induced insulin resistance and inflammation.

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