CJun NH2-terminal Kinase 1 (JNK1): Roles in Metabolic Regulation of Insulin Resistance

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2010 May 11

PMID 20452774

Citations 90

Authors

Guadalupe Sabio

Roger J Davis

Affiliations

Soon will be listed here.

Abstract

The cJun NH(2)-terminal kinase isoform JNK1 is implicated in the mechanism of obesity-induced insulin resistance. Feeding a high-fat diet causes activation of the JNK1 signaling pathway, insulin resistance, and obesity in mice. Germ-line ablation of Jnk1 prevents both diet-induced obesity and insulin resistance. Genetic analysis indicates that the effects of JNK1 on insulin resistance can be separated from effects of JNK1 on obesity. Emerging research indicates that JNK1 plays multiple roles in the regulation of insulin resistance, including altered gene expression, hormone/cytokine production, and lipid metabolism. Together, these studies establish JNK1 as a potential pharmacological target for the development of drugs that might be useful for the treatment of insulin resistance, metabolic syndrome, and type 2 diabetes.

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