The Role of Adipose Tissue Dysfunction in Hepatic Insulin Resistance and T2D

Overview

Journal J Endocrinol

Specialty Endocrinology

Date 2024 Jul 5

PMID 38967989

Authors

Gencer Sancar

Andreas L Birkenfeld

Affiliations

Soon will be listed here.

Abstract

The root cause of type 2 diabetes (T2D) is insulin resistance (IR), defined by the failure of cells to respond to circulating insulin to maintain lipid and glucose homeostasis. While the causes of whole-body insulin resistance are multifactorial, a major contributing factor is dysregulation of liver and adipose tissue function. Adipose dysfunction, particularly adipose tissue-IR (adipo-IR), plays a crucial role in the development of hepatic insulin resistance and the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) in the context of T2D. In this review, we will focus on molecular mechanisms of hepatic insulin resistance and its association with adipose tissue function. A deeper understanding of the pathophysiological mechanisms of the transition from a healthy state to insulin resistance, impaired glucose tolerance, and T2D may enable us to prevent and intervene in the progression to T2D.

Citing Articles

Incretin-responsive human pancreatic adipose tissue organoids: A functional model for fatty pancreas research.

Lorza-Gil E, Strauss O, Ziegler E, Kansy K, Katschke M, Rahimi G Mol Metab. 2024; 91():102067.

PMID: 39549913 PMC: 11625218. DOI: 10.1016/j.molmet.2024.102067.

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