Normative Data for Bone Mass in Healthy Term Infants from Birth to 1 Year of Age

Overview

Journal J Osteoporos

Publisher Wiley

Specialty Orthopedics

Date 2012 Oct 24

PMID 23091773

Citations 21

Authors

Sina Gallo

Catherine A Vanstone

Hope A Weiler

Affiliations

Soon will be listed here.

Abstract

For over 2 decades, dual-energy X-ray absorptiometry (DXA) has been the gold standard for estimating bone mineral density (BMD) and facture risk in adults. More recently DXA has been used to evaluate BMD in pediatrics. However, BMD is usually assessed against reference data for which none currently exists in infancy. A prospective study was conducted to assess bone mass of term infants (37 to 42 weeks of gestation), weight appropriate for gestational age, and born to healthy mothers. The group consisted of 33 boys and 26 girls recruited from the Winnipeg Health Sciences Center (Manitoba, Canada). Whole body (WB) as well as regional sites of the lumbar spine (LS 1-4) and femur was measured using DXA (QDR 4500A, Hologic Inc.) providing bone mineral content (BMC) for all sites and BMD for spine. During the year, WB BMC increased by 200% (76.0 ± 14.2 versus 227.0 ± 29.7 g), spine BMC by 130% (2.35 ± 0.42 versus 5.37 ± 1.02 g), and femur BMC by 190% (2.94 ± 0.54 versus 8.50 ± 1.84 g). Spine BMD increased by 14% (0.266 ± 0.044 versus 0.304 ± 0.044 g/cm(2)) during the year. This data, representing the accretion of bone mass during the first year of life, is based on a representative sample of infants and will aid in the interpretation of diagnostic DXA scans by researchers and health professionals.

Citing Articles

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Maternal and Neonatal Factors Affecting Bone Mineral Content of Indonesian Term Newborns.

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References

Khosla S, Atkinson E, Riggs B, Melton 3rd L . Relationship between body composition and bone mass in women. J Bone Miner Res. 1996; 11(6):857-63. DOI: 10.1002/jbmr.5650110618. View

Weiler H, Fitzpatrick-Wong S, Schellenberg J, Fair D, McCloy U, Veitch R . Minimal enteral feeding within 3 d of birth in prematurely born infants with birth weight < or = 1200 g improves bone mass by term age. Am J Clin Nutr. 2006; 83(1):155-62. DOI: 10.1093/ajcn/83.1.155. View

Halton J, Gaboury I, Grant R, Alos N, Cummings E, Matzinger M . Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program. J Bone Miner Res. 2009; 24(7):1326-34. PMC: 3890351. DOI: 10.1359/jbmr.090202. View

Leonard M, Shults J, Zemel B . DXA estimates of vertebral volumetric bone mineral density in children: potential advantages of paired posteroanterior and lateral scans. J Clin Densitom. 2006; 9(3):265-73. DOI: 10.1016/j.jocd.2006.05.008. View

Specker B, Beck A, Kalkwarf H, Ho M . Randomized trial of varying mineral intake on total body bone mineral accretion during the first year of life. Pediatrics. 1997; 99(6):E12. DOI: 10.1542/peds.99.6.e12. View

Szalay E, Harriman D . Adapting pediatric DXA scanning to clinical orthopaedics. J Pediatr Orthop. 2006; 26(5):686-90. DOI: 10.1097/01.bpo.0000230330.88534.3a. View

Wren T, Liu X, Pitukcheewanont P, Gilsanz V . Bone acquisition in healthy children and adolescents: comparisons of dual-energy x-ray absorptiometry and computed tomography measures. J Clin Endocrinol Metab. 2005; 90(4):1925-8. DOI: 10.1210/jc.2004-1351. View

Binkovitz L, Henwood M, Sparke P . Pediatric DXA: technique, interpretation and clinical applications. Pediatr Radiol. 2008; 38 Suppl 2:S227-39. DOI: 10.1007/s00247-008-0808-y. View

Daniels E, Pettifor J, Schnitzler C, Moodley G, Zachen D . Differences in mineral homeostasis, volumetric bone mass and femoral neck axis length in black and white South African women. Osteoporos Int. 1997; 7(2):105-12. DOI: 10.1007/BF01623684. View

10.

Koo W, Hammami M . Lumbar spine bone measurements in infants: whole-body vs lumbar spine dual X-ray absorptiometry scans. J Clin Densitom. 2002; 5(1):17-25. DOI: 10.1385/jcd:5:1:017. View

11.

Koo W, Bush A, Walters J, Carlson S . Postnatal development of bone mineral status during infancy. J Am Coll Nutr. 1998; 17(1):65-70. DOI: 10.1080/07315724.1998.10720457. View

12.

Avila-Diaz M, Amato D . Increments in whole body bone mineral content associated with weight and length in pre-term and full-term infants during the first 6 months of life. Arch Med Res. 2001; 32(4):288-92. DOI: 10.1016/s0188-4409(01)00291-0. View

13.

Venkataraman P, Ahluwalia B . Total bone mineral content and body composition by x-ray densitometry in newborns. Pediatrics. 1992; 90(5):767-70. View

14.

Tothill P, Hannan W, Wilkinson S . Comparisons between a pencil beam and two fan beam dual energy X-ray absorptiometers used for measuring total body bone and soft tissue. Br J Radiol. 2001; 74(878):166-76. DOI: 10.1259/bjr.74.878.740166. View

15.

Lu P, Cowell C, Briody J, Howman-Giles R . Volumetric bone mineral density in normal subjects, aged 5-27 years. J Clin Endocrinol Metab. 1996; 81(4):1586-90. DOI: 10.1210/jcem.81.4.8636372. View

16.

Vieth R, Cole D, Hawker G, Trang H, Rubin L . Wintertime vitamin D insufficiency is common in young Canadian women, and their vitamin D intake does not prevent it. Eur J Clin Nutr. 2002; 55(12):1091-7. DOI: 10.1038/sj.ejcn.1601275. View

17.

Cole T, Green P . Smoothing reference centile curves: the LMS method and penalized likelihood. Stat Med. 1992; 11(10):1305-19. DOI: 10.1002/sim.4780111005. View

18.

Palacios J, Rodriguez S, Rodriguez J . Intra-uterine long bone growth in small-for-gestational-age infants. Eur J Pediatr. 1992; 151(4):304-7. DOI: 10.1007/BF02072235. View

19.

Taylor A, Konrad P, Norman M, Harcke H . Total body bone mineral density in young children: influence of head bone mineral density. J Bone Miner Res. 1997; 12(4):652-5. DOI: 10.1359/jbmr.1997.12.4.652. View

20.

Gilsanz V, Wren T . Assessment of bone acquisition in childhood and adolescence. Pediatrics. 2007; 119 Suppl 2:S145-9. DOI: 10.1542/peds.2006-2023G. View