Tibial Quantitative Ultrasound Compared to Dual-energy X-ray Absorptiometry in Preterm Infants

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2022 Dec 31

PMID 36587053

Authors

Ariel Tarrell

Matthew Grinsell

Mary Murray

Kimberlee Weaver Lewis

Bradley A Yoder

Sabrina Malone Jenkins

Affiliations

Soon will be listed here.

Abstract

Objective: The gold standard for diagnosing metabolic bone disease in pediatrics is dual-energy x-ray absorptiometry (DXA). Bone quantitative ultrasound (QUS) has increasing applications. This study compared the relationship of DXA to QUS in preterm infants.

Design: Prospective observational study of preterm infants ≤32 weeks gestation or ≤1800 grams at birth. DXA scans measuring bone mineral content (BMC) and tibial QUS scans measuring bone speed of sound (SOS) were obtained near term gestation.

Results: 41 infants had bone scans at mean corrected gestation 37.7 ± 2.1 weeks. BMC and SOS showed weak inverse correlation (R 0.163, p < 0.01). BMC and SOS correlated with parameters at corrected gestational age at the time of the bone scans (p < 0.05-0.001). SOS correlated with birth gestational age (p < 0.001), not BMC.

Conclusions: A statistically significant weak inverse correlation between DXA and QUS was observed. QUS may have advantages over DXA.

Citing Articles

Pulsed Vibro-Acoustic Analysis Technique for Monitoring Bone Health in Preterm Infants: A Pilot Study.

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Diagnostics of Metabolic Bone Disease in Extremely Preterm Infants-Clinical Applicability of Bone Turnover Biochemical Markers and Quantitative Ultrasound.

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