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Maternal and Neonatal Factors Affecting Bone Mineral Content of Indonesian Term Newborns

Overview
Journal Front Pediatr
Specialty Pediatrics
Date 2021 Jun 11
PMID 34113592
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Abstract

Interactions between the genome and intrauterine environment can affect bone mineralization in newborns and even in adult life. Several studies show that intrauterine fetal bone mineralization or early postnatal bone condition influences the risk of osteoporosis in later life. To determine whole body bone mineral content (WB BMC) and factors that influence neonatal WB BMC in Indonesian term newborns. A cross-sectional study was conducted in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. A total of 45 term, appropriate for gestational age (AGA) newborns were included in this study. BMC was assessed by dual-energy x-ray absorptiometry (DXA) in the first week of life. Weight (g), length (cm) and head circumference (cm) were measured at birth. Data on maternal characteristics were obtained from the maternal health records or reported by the mothers. WB BMC measured in the present study (mean ± SD: 33.2 ± 9.3 g) was lower than WB BMC of similar populations in developed countries. Multiple linear regression showed that birth weight, birth length, and gestational age had a positive association with WB BMC ( = 0.048, 0.017, and <0.001, respectively), while maternal cigarette exposure had a negative association with WB BMC ( = 0.012). Male infants had significantly higher of WB BMC than female ( = 0.025). These determinants contribute to 55% variability of WB BMC. WB BMC in Indonesian term newborns is lower than populations in developed countries. Birth weight, length, gestational age, sex, and maternal cigarette exposure during pregnancy are significantly associated with WB BMC observed in Indonesian newborns.

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References
1.
Aji A, Yerizel E, Desmawati D, Lipoeto N . Low Maternal Vitamin D and Calcium Food Intake during Pregnancy Associated with Place of Residence: A Cross-Sectional Study in West Sumatran Women, Indonesia. Open Access Maced J Med Sci. 2019; 7(17):2879-2885. PMC: 6901836. DOI: 10.3889/oamjms.2019.659. View

2.
Cooper C, Harvey N, Cole Z, Hanson M, Dennison E . Developmental origins of osteoporosis: the role of maternal nutrition. Adv Exp Med Biol. 2009; 646:31-9. DOI: 10.1007/978-1-4020-9173-5_3. View

3.
Ramot R, Kachhawa G, Kulshreshtha V, Varshney S, Sankar M, Devasenathipathy K . Bone Mass in Newborns Assessed by DXA - A Systematic Review and Meta-analysis. Indian J Endocrinol Metab. 2019; 23(2):198-205. PMC: 6540894. DOI: 10.4103/ijem.IJEM_681_18. View

4.
Minton S, Steichen J, Tsang R . Bone mineral content in term and preterm appropriate-for-gestational-age infants. J Pediatr. 1979; 95(6):1037-42. DOI: 10.1016/s0022-3476(79)80305-4. View

5.
Venkataraman P, Duke J . Bone mineral content of healthy, full-term neonates. Effect of race, gender, and maternal cigarette smoking. Am J Dis Child. 1991; 145(11):1310-2. DOI: 10.1001/archpedi.1991.02160110102030. View