Maternal Vitamin D Supplementation in Pregnancy and Offspring Outcomes: a Double-blind Randomized Placebo-controlled Trial

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2016 Sep 16

PMID 27628045

Citations 28

Authors

Saroj Kumar Sahoo

Kishore Kumar Katam

Vinita Das

Anjoo Agarwal

Vijayalakshmi Bhatia

Affiliations

Soon will be listed here.

Abstract

We studied bone mineral content (BMC), bone mineral density (BMD), and body composition in offspring of women supplemented with vitamin D during pregnancy. Pregnant women were randomized to receive oral cholecalciferol 60,000 units 4 weekly (group 1), 8 weekly (group 2), or placebo (group 3). All received 1 g calcium daily (groups 1 and 2 without, and group 3 with 400 units vitamin D). Offspring at 12-16 months underwent dual-energy X-ray absorptiometry. Maternal hypovitaminosis D at recruitment was common (serum 25OHD <50 nmol/L in 88 %) and severe (25OHD <25 nmol/L in 46 %). Groups 1 and 2 (n = 23 and 13, median age 14 months) had higher cord blood 25OHD (47.8 ± 13.8 and 31.0 ± 14.0 nmol/L) versus group 3 (n = 16, median age 16 months, 17.8 ± 13.5 nmol/L, p < 0.001). Babies in group 3 had higher whole-body BMC (250.8 ± 42.5 gm) and BMD (0.335 ± 0.033 gm/cm) compared to group 1 (213.1 ± 46.2 gm and 0.295 ± 0.041 gm/cm) and group 2 (202.9 ± 29.9 gm and 0.287 ± 0.023 gm/cm) (p = 0.006 and 0.001, respectively). In multivariate analysis, age, weight z score, and lean body mass remained significant contributors to BMC. Parameters of body composition were comparable among the groups. Vitamin D supplementation to pregnant women with severe deficiency in doses that improved cord blood 25OHD did not result in improved bone health or body composition in offspring at 12-16 months, compared to a dose too small to improve 25OHD levels.

Citing Articles

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